Multifaceted role of cancer educated platelets in survival of cancer cells

被引：29
作者：
Asghar, Sidra [1 ]
Parvaiz, Fahed [2 ]
Manzoor, Sobia [1 ]
机构：
[1] Natl Univ Sci & Technol, Atta Ur Rahman Sch Appl Biosci, H12, Islamabad 44000, Pakistan
[2] COMSATS Univ, Dept Biosci, Islamabad, Pakistan
来源：
THROMBOSIS RESEARCH | 2019年 / 177卷
关键词：
Tumor educated platelets; TCIPA; Cancer; Metastasis; Angiogenesis; Thrombosis; ENDOTHELIAL GROWTH-FACTOR; NATURAL-KILLER-CELLS; LYSOPHOSPHATIDIC ACID; TUMOR-GROWTH; P-SELECTIN; TISSUE FACTOR; MATRIX METALLOPROTEINASES; NK CELLS; METASTASIS; ACTIVATION;
D O I：
10.1016/j.thromres.2019.02.026
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets, the derivatives of megakaryocytes, pose dynamic biological functions such as homeostasis and wound healing. The mechanisms involved in these processes are utilized by cancerous cells for proliferation and metastasis. Platelets through their activation establish an aggregate termed as Tumor cell induced platelet aggregation (TCIPA) that aids in establishing a niche for the primary tumor at secondary site while recruiting granulocytes and monocytes. The study of these close interactions between the tumor and the platelets can be exploited as biomarkers in liquid biopsy for early cancer detection, thereby increasing the life expectancy of cancer patients.
引用
收藏
页码：42 / 50
页数：9
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