The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

被引：106

作者：

Markey, Kate A. ^{[1
,2
]}

Schluter, Jonas ^{[3
]}

Gomes, Antonio L. C. ^{[4
]}

Littmann, Eric R. ^{[4
]}

Pickard, Amanda J. ^{[5
]}

Taylor, Bradford P. ^{[3
]}

Giardina, Paul A. ^{[1
,4
]}

Weber, Daniela ^{[5
]}

Dai, Anqi ^{[4
]}

Docampo, Melissa D. ^{[2
,4
]}

Armijo, Gabriel K. ^{[4
]}

Slingerland, Ann E. ^{[4
]}

Slingerland, John B. ^{[1
]}

Nichols, Katherine B. ^{[4
]}

Brereton, Daniel G. ^{[1
]}

Clurman, Annelie G. ^{[1
]}

Ramos, Ruben J. ^{[6
]}

Rao, Arka ^{[6
]}

Bush, Amy ^{[7
]}

Bohannon, Lauren ^{[7
]}

Covington, Megan ^{[7
]}

Lew, Meagan V. ^{[7
]}

Rizzieri, David A. ^{[7
]}

Chao, Nelson ^{[7
]}

Maloy, Molly ^{[1
]}

Cho, Christina ^{[1
,2
]}

Politikos, Ioannis ^{[1
,2
]}

Giralt, Sergio ^{[1
,2
]}

Taur, Ying ^{[2
,8
]}

Pamer, Eric G. ^{[2
,4
,8
]}

Holler, Ernst ^{[5
]}

Perales, Miguel-Angel ^{[1
,2
]}

Ponce, Doris M. ^{[1
]}

Devlin, Sean M. ^{[9
]}

Xavier, Joao ^{[3
]}

Sung, Anthony D. ^{[7
]}

Peled, Jonathan U. ^{[1
,2
]}

Cross, Justin R. ^{[6
]}

van den Brink, Marcel R. M. ^{[1
,2
,4
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Dept Med, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Computat & Syst Biol, 1275 York Ave, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Immunol, Sloan Kettering Inst, New York, NY 10021 USA

[5] Univ Med Ctr, Internal Med 3, Dept Hematol & Oncol, Regensburg, Germany

[6] Mem Sloan Kettering Canc Ctr, Donald B & Catherine C Marron Canc Metab Ctr, 1275 York Ave, New York, NY 10021 USA

[7] Duke Univ, Med Ctr, Dept Med, Div Hematol Malignancies & Cellular Therapy, Durham, NC 27710 USA

[8] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY 10021 USA

[9] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

来源：

BLOOD | 2020年 / 136卷 / 01期

基金：

美国国家卫生研究院;

关键词：

VERSUS-HOST-DISEASE; GUT MICROBIOME; CELL;

D O I：

10.1182/blood.2019003369

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early complications, predominantly infection and acute graft-versus-host disease (GVHD). We examined the potential relationship of the microbiome with chronic GVHD (cGVHD) by analyzing stool and plasma samples collected late after allo-HCT using a case-control study design. We found lower circulating concentrations of the microbe-derived short-chain fatty acids (SCFAs) propionate and butyrate in day 100 plasma samples from patients who developed cGVHD, compared with those who remained free of this complication, in the initial case-control cohort of transplant pa-tients and in a further cross-sectional cohort from an independent transplant center. An additional cross-sectional patient cohort from a third transplant center was analyzed; however, serum (rather than plasma) was available, and the differences in SCFAs observed in the plasma samples were not recapitulated. In sum, our findings from the primary case-control cohort and 1 of 2 cross-sectional cohorts explored suggest that the gastrointestinal microbiome may exert immuno-modulatory effects in allo-HCT patients at least in part due to control of systemic concentrations of microbe-derived SCFAs.

引用

页码：130 / 136

页数：7

共 33 条

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