Nanoparticle-functionalized microcapsules for in vitro delivery and sensing

被引：12

作者：

Carregal-Romero, Susana

Ochs, Markus

Parak, Wolfgang J. ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Phys, D-35032 Marburg, Germany

来源：

NANOPHOTONICS | 2012年 / 1卷 / 02期

关键词：

polyelectrolyte capsules; colloidal nanoparticles; quantum dots; magnetic nanoparticles; plasmonic nanoparticles; multifunctionality; delivery system; sensors; hybrid particles; POLYELECTROLYTE MULTILAYER CAPSULES; POLYMER CAPSULES; CELLULAR UPTAKE; RELEASE; TRANSFECTION; MOLECULES; COLLOIDS; CARRIERS; THERAPY; CELLS;

D O I：

10.1515/nanoph-2012-0014

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Inorganic nanoparticles such as magnetic nanoparticles, fluorescent quantum dots, and plasmonic nanoparticles can be used as building blocks for designing multifunctional systems based on polymeric capsules. The properties of the inorganic nanoparticles hereby are harnessed to provide additional functionality to the polymer capsules. Biological applications towards in vitro sensing and delivery are discussed. Examples will be given in which magnetic nanoparticles are used to direct capsules with magnetic field gradients, colloidal quantum dots are used to identify capsules via the formation of optical barcodes, and gold nanoparticles are used as light-controlled heat-sources for opening capsules and releasing macromolecules from their cavity upon optical excitation. This demonstrates that combination of inorganic nanoparticles and organic/polymeric molecules as carrier matrices allow for tailoring multifunctional hybrid particles for practical applications.

引用

页码：171 / 180

页数：10

共 68 条

[21] Synthesis and evaluation of gold nanoparticle-modified polyelectrolyte capsules under microwave irradiation for remotely controlled release for cargo [J].