Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

被引：37

作者：

Chen, Bing-Zhi ^{[1
]}

Zhi, Man-Ling ^{[1
]}

Wang, Chuang-Xin ^{[1
]}

Chu, Xue-Qiang ^{[1
]}

Shen, Zhi-Liang ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 07期

关键词：

KETENE SILYL ACETALS; IN-SITU GENERATION; ORGANOINDIUM REAGENTS; AQUEOUS-MEDIA; TRIORGANOINDIUM REAGENTS; UNSATURATED HALIDES; ARYLINDIUM REAGENTS; DIRECT INSERTION; ACID-CHLORIDE; ONE-POT;

D O I：

10.1021/acs.orglett.8b00441

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

引用

页码：1902 / 1905

页数：4

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