It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

被引：69
作者：
Farrera, Consol [1 ]
Fadeel, Bengt [1 ]
机构：
[1] Karolinska Inst, Div Mol Toxicol, Nanosafety & Nanomed Lab, Inst Environm Med, S-17177 Stockholm, Sweden
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2015年 / 95卷
基金：
瑞典研究理事会; 芬兰科学院;
关键词：
Nanomaterials; Nanotoxicology; Macrophages; Bio-corona; Inflammasome; Danger signals; WALLED CARBON NANOTUBES; PROTEIN CORONA; NLRP3; INFLAMMASOME; DENDRITIC CELLS; PULMONARY INFLAMMATION; NANOPARTICLE UPTAKE; GOLD NANOPARTICLES; NALP3; CELLULAR UPTAKE; GRAPHENE OXIDE;
D O I：
10.1016/j.ejpb.2015.03.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The immune system represents our primary defense system against foreign intrusion, including pathogens as well as particles. In order to understand the potential toxicity of engineered nanomaterials of ever increasing sophistication, it is necessary to understand the sophistication of the immune system with its multiple, specialized cell types and soluble mediators. Moreover, it is important to consider not only material-intrinsic properties of the pristine nanomaterial, but also the acquired, context-dependent 'identity' of a nanomaterial in a living system resulting from the adsorption of biomolecules on its surface. The immune system has evolved to recognize a vast array of microbes through so-called pattern recognition; we discuss in the present review whether engineered nanomaterials with or without a corona of biomolecules could also be sensed as 'pathogens' by immune-competent cells. (C) 2015 Elsevier B.V. All rights reserved.
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页码：3 / 12
页数：10
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