Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

被引：79
作者：
Ackerman, Dorothy L. [1 ]
Craft, Kelly M. [1 ]
Doster, Ryan S. [2 ]
Weitkamp, Jorn-Hendrik [2 ,3 ]
Aronoff, David M. [2 ]
Gaddy, Jennifer A. [2 ,4 ]
Townsend, Steven D. [1 ,5 ]
机构：
[1] Vanderbilt Univ, Dept Chem, Stevenson Ctr 7330, Box 1583, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Med Ctr, Dept Med, 1161 21st Ave South,D-3100 Med Ctr North, Nashville, TN 37232 USA
[3] Monroe Carell Jr Childrens Hosp Vanderbilt, Dept Pediat, 2200 Childrens Way,Suite 2404, Nashville, TN 37232 USA
[4] Tennessee Valley Healthcare Syst, Dept Vet Affairs, 1310 24th Ave South, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Inst Chem Biol, 896 Preston Res Bldg, Nashville, TN 37232 USA
来源：
ACS INFECTIOUS DISEASES | 2018年 / 4卷 / 03期
关键词：
S; agalactiae; GBS; aureus; A; baumannii; antimicrobial; antibiofilm; BLOOD-GROUP; INFECTIONS EPIDEMIOLOGY; N-ACETYLCYSTEINE; BIOFILM; POLYSACCHARIDES; CHILDHOOD; MORTALITY; FREQUENCY; SECRETOR; INFANTS;
D O I：
10.1021/acsinfecdis.7b00183
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.
引用
收藏
页码：315 / 324
页数：19
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