Vitiligo

被引：687

作者：

Ezzedine, Khaled ^{[1
,2
]}

Eleftheriadou, Viktoria ^{[3
]}

Whitton, Maxine ^{[3
]}

van Geel, Nanja ^{[4
]}

机构：

[1] Hop Pellegrin, Natl Ctr Rare Skin Disorders, Dept Dermatol & Paediat Dermatol, F-33076 Bordeaux, France

[2] Univ Bordeaux 2, INSERM, U1035, F-33076 Bordeaux, France

[3] Univ Nottingham, Ctr Evidence Based Dermatol, Nottingham NG7 2RD, England

[4] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium

来源：

LANCET | 2015年 / 386卷 / 9988期

关键词：

QUALITY-OF-LIFE; DEPIGMENTATION THERAPY; KOEBNERS PHENOMENON; T-CELLS; INCREASED SENSITIVITY; GENERALIZED VITILIGO; SUSCEPTIBILITY LOCI; CHILDHOOD VITILIGO; HUMAN MELANOCYTES; IMMUNE-RESPONSE;

D O I：

10.1016/S0140-6736(14)60763-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitiligo, an acquired pigmentary disorder of unknown origin, is the most frequent cause of depigmentation worldwide, with an estimated prevalence of 1%. The disorder can be psychologically devastating and stigmatising, especially in dark skinned individuals. Vitiligo is clinically characterised by the development of white macules due to the loss of functioning melanocytes in the skin or hair, or both. Two forms of the disease are well recognised: segmental and non-segmental vitiligo (the commonest form). To distinguish between these two forms is of prime importance because therapeutic options and prognosis are quite different. The importance of early treatment and understanding of the profound psychosocial effect of vitiligo will be emphasised throughout this Seminar.

引用

页码：74 / 84

页数：11

共 118 条

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