Identification of tetrodotoxin-producing bacteria from goby Yongeichthys criniger

被引：10

作者：

Wei, Fen ^{[1
]}

Ma, Tinglong ^{[1
]}

Gong, Xiaoling ^{[1
]}

Zhang, Na ^{[1
]}

Bao, Baolong ^{[1
]}

机构：

[1] Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China

来源：

TOXICON | 2015年 / 104卷

关键词：

Yongeichthys criniger; TTX-producing bacteria; Tetrodotoxin; Enterobacter cloaca; Rahnella aquatilis; Goby; MARINE TOXINS; SKIN; AEROMONAS; GASTROPOD; DIVERSITY; ORIGIN; NEWT;

D O I：

10.1016/j.toxicon.2015.07.335

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Toxic goby fish (Yongeichthys criniger) containing tetrodotoxin (TTX), from Zhanjiang, Guangdong province, China, were screened for TTX-producing bacteria. Two toxic bacterial strains were isolated from the liver of Y. criniger and respectively denoted XC-3 and XL-1. TTX production by the strains was confirmed by mouse bioassay, enzyme-linked immunosorbent assay and high performance liquid chromatography coupled with mass spectrometry. Based on morphological, physiological and biochemical characteristics and 16S rDNA phylogenetic analysis, strain XL-3 was identified as Enterobacter cloaca and XL-1 was closely related to Rahnella aquatilis. These findings show for the first time that TTX-producing bacteria are symbiotic bacteria in goby and suggest that bacterial strains are at least partially responsible for TTX accumulation in Y. criniger. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：46 / 51

页数：6

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