Argon plasma coagulation is an effective treatment for hereditary hemorrhagic telangiectasia patients with severe nosebleeds

被引：14

作者：

Pagella, Fabio ^{[1
]}

Matti, Elina ^{[1
]}

Chu, Francesco ^{[1
]}

Pusateri, Alessandro ^{[1
]}

Tinelli, Carmine ^{[2
]}

Olivieri, Carla ^{[3
]}

Canzonieri, Cecilia ^{[3
,4
]}

Boeri, Laura ^{[3
]}

Ornati, Federica ^{[1
,3
]}

Danesino, Cesare ^{[3
]}

机构：

[1] Univ Pavia, Dept Otorhinolaryngol, I-27100 Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Clin Epidemiol & Biometr Unit, I-27100 Pavia, Italy

[3] Univ Pavia, Gen Biol & Med Genet Dept Mol Med, I-27100 Pavia, Italy

[4] Fdn IRCCS Policlin San Matteo, GI Endoscopy Unit, Pavia, Italy

来源：

ACTA OTO-LARYNGOLOGICA | 2013年 / 133卷 / 02期

关键词：

HHT; epistaxis; Rendu-Osler-Weber syndrome; endoscopic; mini-invasive; blood transfusion; quality of life; EPISTAXIS; MANAGEMENT; LASER; HHT;

D O I：

10.3109/00016489.2012.718097

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Conclusions: In contrast to the current trend according to which the treatment of hereditary hemorrhagic telangiectasia (HHT) epistaxis depends on clinical severity, argon plasma coagulation (APC) has also proven to be effective as a first-line procedure in patients with severe nosebleeds. Furthermore, with this approach patients are free from requirements for blood transfusions for a long time in the vast majority of cases. Objective: The aim of this study was to test the efficacy of APC treatment as a first-line procedure in HHT patients affected by severe epistaxis. Methods: From 1996 until 2011, 252 HHT patients were treated with APC in our clinic. We selected 26 patients with severe epistaxis for whom the need for blood transfusion had been recorded. This group of patients was asked to answer a questionnaire that aimed to evaluate the severity of epistaxis (defined by its intensity, frequency, and duration), to assess the duration of the benefit of treatment and to evaluate the number of blood transfusions required before and after treatment. Results: After APC treatment, a statistically significant decrease in all epistaxis parameters was recorded and most patients did not need blood transfusions for several years after the procedure.

引用

页码：174 / 180

页数：7

共 19 条

[1] Al-Deen S, 2008, RHINOLOGY, V46, P281
[2] BENBASSAT M, 1978, BRIT J PLAST SURG, V31, P157, DOI 10.1016/0007-1226(78)90069-3
[3] Argon plasma coagulation for the treatment of hereditary hemorrhagic telangiectasia[J]. Bergler, W;Riedel, F;Baker-Schreyer, A;Juncker, C;Hörmann, K. LARYNGOSCOPE, 1999(01)
[4] Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia[J]. Bergler, W;Sadick, H;Riedel, F;Götte, K;Hörmann, K. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2002(03)
[5] Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia[J]. Cottin, V;Plauchu, H;Bayle, JY;Barthelet, M;Revel, D;Cordier, JF. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004(09)
[6] International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia[J]. Faughnan, M. E.;Palda, V. A.;Garcia-Tsao, G.;Geisthoff, U. W.;McDonald, J.;Proctor, D. D.;Spears, J.;Brown, D. H.;Buscarini, E.;Chesnutt, M. S.;Cottin, V.;Ganguly, A.;Gossage, J. R.;Guttmacher, A. E.;Hyland, R. H.;Kennedy, S. J.;Korzenik, J.;Mager, J. J.;Ozanne, A. P.;Piccirillo, J. F.;Picus, D.;Plauchu, H.;Porteous, M. E. M.;Pyeritz, R. E.;Ross, D. A.;Sabba, C.;Swanson, K.;Terry, P.;Wallace, M. C.;Westermann, C. J. J.;White, R. I.;Young, L. H.;Zarrabeitia, R. JOURNAL OF MEDICAL GENETICS, 2011(02)
[7] Treatment of recurrent epistaxis in HHT[J]. Geisthoff, U. W.;Fiorella, M. L.;Fiorella, R. CURRENT PHARMACEUTICAL DESIGN, 2006(10)
[8] GLUCKMAN JL, 1994, LARYNGOSCOPE, V104, P1174
[9] Hereditary haemorrhagic telangiectasia: a clinical and scientific review[J]. Govani, Fatima S.;Shovlin, Claire L. EUROPEAN JOURNAL OF HUMAN GENETICS, 2009(07)
[10] An Epistaxis Severity Score for Hereditary Hemorrhagic Telangiectasia[J]. Hoag, Jeffrey B.;Terry, Peter;Mitchell, Sally;Reh, Douglas;Merlo, Christian A. LARYNGOSCOPE, 2010(04)

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