A metal-free visible-light-promoted phosphorylation/cyclization reaction in water towards 3-phosphorylated benzothiophenes

被引：45

作者：

Yuan, Xiao-Ya ^{[1
]}

Zeng, Fan-Lin ^{[1
]}

Zhu, Hu-Lin ^{[1
]}

Liu, Yan ^{[1
,2
]}

Lv, Qi-Yan ^{[1
]}

Chen, Xiao-Lan ^{[1
]}

Peng, Lifen ^{[3
]}

Yu, Bing ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[2] Xinyang Agr & Forestry Univ, Coll Biol & Pharmaceut Engn, Xinyang 464000, Peoples R China

[3] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Controllable Preparat & Funct, Key Lab Theoret Organ Chem & Funct Mol,Minist Edu, Xiangtan 411201, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 14期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

INDUCED DEOXYGENATIVE C2-SULFONYLATION; QUINOLINE N-OXIDES; C-H; EFFICIENT SYNTHESIS; ACIDS; CATALYSIS; AMINES; THIOLS;

D O I：

10.1039/d0qo00222d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free visible-light-induced 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN)-catalyzed phosphorylation/cyclization reaction was developed in water at room temperature for the synthesis of 3-phosphorylated benzothiophenes. Notably, the conventional organic solvents were avoided. More importantly, this silver-free system circumvents the generation of by-product benzo[b]phosphole oxides. With this strategy, a series of 3-phosphorylated benzothiophenes bearing various functional groups were synthesized in good to excellent yields.

引用

页码：1884 / 1889

页数：6

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