Early stage human colorectal cancer: Prognostic value of nm23-H1 protein overexpression

被引：18
作者：
Indinnimeo, M
Giarnieri, E
Stazi, A
Cicchini, C
Brozzetti, S
Valli, C
Carreca, I
Vecchione, A
机构：
[1] UNIV ROMA LA SAPIENZA,POLICLIN UMBERTO I,CATTEDRA CITOPATOL 1,I-00161 ROME,ITALY
[2] UNIV ROMA LA SAPIENZA,CLIN CHIRURG 1,ROME,ITALY
[3] UNIV PALERMO,CATTEDRA ONCOL CLIN,PALERMO,ITALY
来源：
CANCER LETTERS | 1997年 / 111卷 / 1-2期
关键词：
nm23; gene; colorectal cancer; recurrence; prognostic factors;
D O I：
10.1016/S0304-3835(96)04472-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nm23 gene codifies for a nucleoside diphosphate kinase allowing the intracellular transduction of the signals. In colorectal cancer nm23 protein expression seems related to the progression of the disease. By immunohistochemistry we have studied the intracytoplasmatic nm23 H1 protein expression in 20 patients affected by colorectal cancer at initial stage. In 12 cases it resulted elevated and in four the disease recurred. The overexpression was not correlated with other prognostic factors. Nm23 HI-positive patients affected by colorectal cancer at initial;stage could be considered at risk for disease recurrence and included in a more frequent follow-up protocol. (C) 1997 Elsevier Science Ireland Ltd. All rights reserved
引用
收藏
页码：1 / 5
页数：5
相关论文
共 50 条
[31]   γ-Catenin is an independent prognostic marker in early stage colorectal cancer [J].
Jutta Maria Nagel ;
Lydia Kriegl ;
David Horst ;
Jutta Engel ;
Shiva Gautam ;
Christos S. Mantzoros ;
Thomas Kirchner ;
Burkhard Göke ;
Frank Thomas Kolligs .
International Journal of Colorectal Disease, 2010, 25 :1301-1309
[32]   γ-Catenin is an independent prognostic marker in early stage colorectal cancer [J].
Nagel, Jutta Maria ;
Kriegl, Lydia ;
Horst, David ;
Engel, Jutta ;
Gautam, Shiva ;
Mantzoros, Christos S. ;
Kirchner, Thomas ;
Goeke, Burkhard ;
Kolligs, Frank Thomas .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2010, 25 (11) :1301-1309
[33]   Expression of (NM23-H1) gene in acute lymphocytic leukemia and its clinical significance [J].
El Ansary, Mervat M. ;
Allah, Nagwa Abd ;
Emara, Nahed A. ;
el Tablawy, Manar M. ;
Mahmoud, Shereen .
ARCHIVES OF MEDICAL SCIENCE, 2009, 5 (02) :241-247
[34]   Nm23-H1 can induce cell cycle arrest and apoptosis in B cells [J].
Choudhuri, Tathagata ;
Murakami, Masanao ;
Kaul, Rajeev ;
Sahu, Sushil K. ;
Mohanty, Suchitra ;
Verma, Subhash C. ;
Kumar, Pankaj ;
Robertson, Erle S. .
CANCER BIOLOGY & THERAPY, 2010, 9 (12) :1065-1078
[35]   Overexpression of NDP kinase nm23 associated with ploidy image analysis in colorectal cancer [J].
Giarnieri, E ;
Alderisio, M ;
Valli, C ;
Vecchione, A ;
Forte, A ;
Turano, R ;
Pulcini, M .
ANTICANCER RESEARCH, 1995, 15 (5B) :2049-2053
[36]   Prognostic value of lymph node ratio in stage III colorectal cancer [J].
Wong, K. P. ;
Poon, J. T. C. ;
Fan, J. K. M. ;
Law, W. L. .
COLORECTAL DISEASE, 2011, 13 (10) :1116-1122
[37]   Expression signature and prognostic value of CREC gene family in human colorectal cancer [J].
Ning, Junya ;
Liu, Min ;
Shen, Jing ;
Wang, Deping ;
Gao, Lijuan ;
Li, Huiyu ;
Cao, Jimin .
BMC CANCER, 2023, 23 (01)
[38]   The Regulating Effect of the nm23-H1 Gene for PKA Signal Pathway of Lung Cancer Cell and Its Molecular Mechanism [J].
Dingbiao LI Lunxu LIU Jun CHEN Sen WEI Gang CHEN Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOUTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer Institute Tianjin Medical University Hospital Tianjin ChinaDepartment of Thoracic Surgery The st University Hospital Kunming Medical Colleage Kunming ChinaDepartment of Thoracic Surgery West China Hospital Sichuan University Chengdu China .
中国肺癌杂志, 2009, 12 (06) :485-487
[39]   Overexpression of an mRNA-binding protein in human colorectal cancer [J].
Ross, J ;
Lemm, I ;
Berberet, B .
ONCOGENE, 2001, 20 (45) :6544-6550
[40]   Overexpression of an mRNA-binding protein in human colorectal cancer [J].
Jeffrey Ross ;
Ira Lemm ;
Brad Berberet .
Oncogene, 2001, 20 :6544-6550
12345