Early stage human colorectal cancer: Prognostic value of nm23-H1 protein overexpression

被引：18

作者：

Indinnimeo, M

Giarnieri, E

Stazi, A

Cicchini, C

Brozzetti, S

Valli, C

Carreca, I

Vecchione, A

机构：

[1] UNIV ROMA LA SAPIENZA,POLICLIN UMBERTO I,CATTEDRA CITOPATOL 1,I-00161 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,CLIN CHIRURG 1,ROME,ITALY

[3] UNIV PALERMO,CATTEDRA ONCOL CLIN,PALERMO,ITALY

来源：

CANCER LETTERS | 1997年 / 111卷 / 1-2期

关键词：

nm23; gene; colorectal cancer; recurrence; prognostic factors;

D O I：

10.1016/S0304-3835(96)04472-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nm23 gene codifies for a nucleoside diphosphate kinase allowing the intracellular transduction of the signals. In colorectal cancer nm23 protein expression seems related to the progression of the disease. By immunohistochemistry we have studied the intracytoplasmatic nm23 H1 protein expression in 20 patients affected by colorectal cancer at initial stage. In 12 cases it resulted elevated and in four the disease recurred. The overexpression was not correlated with other prognostic factors. Nm23 HI-positive patients affected by colorectal cancer at initial;stage could be considered at risk for disease recurrence and included in a more frequent follow-up protocol. (C) 1997 Elsevier Science Ireland Ltd. All rights reserved

引用

收藏

页码：1 / 5

页数：5

相关论文

共 50 条

[21] The Regulating Mechanism of Nm23-H1 Gene for FAK Signal Pathway in Human Lung Cancer Cell Line L9981 [J].

Dejun KONG Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOUTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment Tianjin Lung Cancer Institute Tianjin Medical University General Hospital Tianjin China Department of Medical Oncology Chengdu Hospital Chengdu China The Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province West China Hospital Sichuan University Chengdu China .

中国肺癌杂志, 2009, 12 (06) :489-490

[22] Multiple mechanisms underlie metastasis suppressor function of NM23-H1 in melanoma [J].

Novak, Marian ;

Jarrett, Stuart G. ;

McCorkle, Joseph R. ;

Mellon, Isabel ;

Kaetzel, David M. .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2011, 384 (4-5) :433-438

[23] Mesothelin expression has prognostic value in stage / colorectal cancer [J].

Shiraishi, Takehiro ;

Shinto, Eiji ;

Mochizuki, Satsuki ;

Tsuda, Hitoshi ;

Kajiwara, Yoshiki ;

Okamoto, Koichi ;

Einama, Takahiro ;

Hase, Kazuo ;

Ueno, Hideki .

VIRCHOWS ARCHIV, 2019, 474 (03) :297-307

[24] Mesothelin expression has prognostic value in stage ΙΙ/ΙΙΙ colorectal cancer [J].

Takehiro Shiraishi ;

Eiji Shinto ;

Satsuki Mochizuki ;

Hitoshi Tsuda ;

Yoshiki Kajiwara ;

Koichi Okamoto ;

Takahiro Einama ;

Kazuo Hase ;

Hideki Ueno .

Virchows Archiv, 2019, 474 :297-307

[25] Prognostic value of cyclin B1 protein expression in colorectal cancer [J].

Grabsch, H ;

Lickvers, K ;

Hansen, O ;

Takeno, S ;

Willers, R ;

Stock, W ;

Gabbert, HE ;

Mueller, W .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2004, 122 (04) :511-516

[26] Nm23-H1 Protein Binds to APE1 at AP Sites and Stimulates AP Endonuclease Activity Following Ionizing Radiation of the Human Lung Cancer A549 Cells [J].

Zhang, Zhi-Min ;

Yang, Xue-Qin ;

Wang, Dong ;

Wang, Ge ;

Yang, Zhen-Zhou ;

Qing, Yi ;

Yang, Zhi-Xiang ;

Li, Meng-Xia ;

Xiang, De-Bing .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2011, 61 (03) :561-572

[27] Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer [J].

Kahlert, Christoph ;

Lerbs, Tristan ;

Pecqueux, Mathieu ;

Herpel, Esther ;

Hoffmeister, Michael ;

Jansen, Lina ;

Brenner, Hermann ;

Chang-Claude, Jenny ;

Blaeker, Hendrik ;

Kloor, Matthias ;

Roth, Wilfried ;

Pilarsky, Christian ;

Rahbari, Nuh N. ;

Schoelch, Sebastian ;

Bork, Ulrich ;

Reissfelder, Christoph ;

Weitz, Juergen ;

Aust, Daniela ;

Koch, Moritz .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (09) :2104-2113

[28] EVALUATION OF THE PROGNOSTIC VALUE OF nm23 GENE EXPRESSION IN BREAST CANCER [J].

刘红 ;

毛慧生 ;

傅西林 ;

方志沂 ;

冯玉梅 ;

范宇 ;

李树玲 .

Chinese Journal of Cancer Research, 2002, (02) :13-17

[29] TRIM23 overexpression is a poor prognostic factor and contributes to carcinogenesis in colorectal cancer [J].

Han, Yudong ;

Tan, Ye ;

Zhao, Yuanyuan ;

Zhang, Yongchun ;

He, Xinjia ;

Yu, Li ;

Jiang, Haiping ;

Lu, Haijun ;

Tian, Haiying .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (10) :5491-5500

[30] Tumor microbiome analysis provides prognostic value for patients with stage III colorectal cancer [J].

Kim, Jae Hyun ;

Yu, Jongwook ;

Kim, Dong Keon ;

Lee, Seunghun ;

Lee, Seung Hyun ;

Ahn, Byung Kwon ;

Kim, Tae Il ;

Park, Seun Ja .

FRONTIERS IN ONCOLOGY, 2023, 13

← 1 2 3 4 5 →