Early stage human colorectal cancer: Prognostic value of nm23-H1 protein overexpression

被引：18

作者：

Indinnimeo, M

Giarnieri, E

Stazi, A

Cicchini, C

Brozzetti, S

Valli, C

Carreca, I

Vecchione, A

机构：

[1] UNIV ROMA LA SAPIENZA,POLICLIN UMBERTO I,CATTEDRA CITOPATOL 1,I-00161 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,CLIN CHIRURG 1,ROME,ITALY

[3] UNIV PALERMO,CATTEDRA ONCOL CLIN,PALERMO,ITALY

来源：

CANCER LETTERS | 1997年 / 111卷 / 1-2期

关键词：

nm23; gene; colorectal cancer; recurrence; prognostic factors;

D O I：

10.1016/S0304-3835(96)04472-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nm23 gene codifies for a nucleoside diphosphate kinase allowing the intracellular transduction of the signals. In colorectal cancer nm23 protein expression seems related to the progression of the disease. By immunohistochemistry we have studied the intracytoplasmatic nm23 H1 protein expression in 20 patients affected by colorectal cancer at initial stage. In 12 cases it resulted elevated and in four the disease recurred. The overexpression was not correlated with other prognostic factors. Nm23 HI-positive patients affected by colorectal cancer at initial;stage could be considered at risk for disease recurrence and included in a more frequent follow-up protocol. (C) 1997 Elsevier Science Ireland Ltd. All rights reserved

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页码：1 / 5

页数：5

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