Microtubules in Dendritic Spine Development

被引：176

作者：

Gu, Jiaping ^{[1
]}

Firestein, Bonnie L. ^{[2
]}

Zheng, James Q. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 46期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

cytoskeleton; hippocampus; plasticity; synapse; neurotrophin; synaptic plasticity;

D O I：

10.1523/JNEUROSCI.2509-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation. Furthermore, stabilization and inhibition of MTs by low doses of taxol and nocodazole enhance and impair spine formation elicited by BDNF (brain-derived neurotrophic factor), respectively. Therefore, MTs play an important role in the control and regulation of dendritic spine development and plasticity.

引用

页码：12120 / 12124

页数：5

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