Proteomic analysis of extracellular matrix and vesicles

被引：46

作者：

Xiao, Zhen ^{[1
]}

Blonder, Josip ^{[1
]}

Zhou, Ming ^{[1
]}

Veenstra, Timothy D. ^{[1
]}

机构：

[1] NCI, SAIC Frederick Inc, Adv Technol Program, Lab Prote & Analyt Technol, Ft Detrick, MD 21702 USA

来源：

JOURNAL OF PROTEOMICS | 2009年 / 72卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Extracellular matrix; Extracellular vesicles; Exosomes; Mass spectrometry; Proteomics; CELL-DERIVED EXOSOMES; MASS-SPECTROMETRIC PROTEOMICS; SHED MEMBRANE-VESICLES; BREAST-CARCINOMA CELLS; UROKINASE PLASMINOGEN-ACTIVATOR; HEPARAN-SULFATE PROTEOGLYCANS; RETICULOCYTES IN-VITRO; PEPTIDE-BASED VACCINE; SYNAPTIC VESICLES; TUMOR MICROENVIRONMENT;

D O I：

10.1016/j.jprot.2008.11.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The extracellular matrix (ECM) is the connective tissue component generated and secreted by cells to provide structural and functional support, while extracellular vesicles are distinct membrane-enclosed structures present outside of eucaryotic cells that carry out distinct biological functions. Different cell types release distinct populations of vesicles that fulfill various functions. Exosomes are vesicles commonly secreted by a variety of cells, whereas matrix vesicles (MVs) are specifically produced and secreted by bone cells to facilitate the formation of the ECM. This article focuses on the characteristics of the ECM and extracellular vesicles, and reviews the latest progress in applying proteomic technologies to analyze these features. The findings and implications in developmental biology, tumor biology, immunology, biomarker discovery, and vaccine research are also discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：34 / 45

页数：12

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