Contrast-enhanced ultrasound detects perfusion defects in an ex vivo porcine liver model: a useful tool for the study of hepatic reperfusion

被引：5

作者：

Alzaraa, Ahmed ^{[1
]}

Al-Leswas, Dhya ^{[1
]}

Chung, Wen Yuan ^{[1
]}

Gravante, Gianpiero ^{[1
]}

Bruno, Morgan ^{[2
]}

West, Kevin ^{[3
]}

Dennison, Ashley ^{[1
]}

Lloyd, David ^{[1
]}

机构：

[1] Univ Hosp Leicester, Leicester Gen Hosp, Dept Hepatobiliary & Pancreat Surg, Leicester LE5 4PW, Leics, England

[2] Univ Hosp Leicester, Leicester Gen Hosp, Dept Radiol, Leicester LE5 4PW, Leics, England

[3] Univ Hosp Leicester, Leicester Gen Hosp, Dept Histopathol, Leicester LE5 4PW, Leics, England

来源：

JOURNAL OF ARTIFICIAL ORGANS | 2013年 / 16卷 / 04期

关键词：

Liver; Transplant; Ultrasound; Contrast agents; Ischemia; CYTOKINE RESPONSE; TRANSPLANTATION; MICROBUBBLES; AGENTS; SONOGRAPHY; EXPERIENCE; ABLATION; KIDNEY; TUMORS; SERUM;

D O I：

10.1007/s10047-013-0717-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Following transplantation, areas of hypoperfusion can be associated with metabolic changes and poor organ recovery. Our study evaluated contrast-enhanced ultrasound (CEUS) agents for the detection of such areas. Livers were collected from ten pigs, connected to extracorporeal circuits and perfused using autologous blood. After 1 and 4 h livers were scanned with an ultrasound machine following the administration of CEUS agents. Biopsies from perfused and non-perfused areas were collected. The entire parenchyma enhanced strongly on non-contrast ultrasound at 1 h with no perfusion defects. Four hours later multiple perfusion defects manifested not evident with non-contrast ultrasound. Histology confirmed non-perfused areas corresponded to ischemic zones. In our model the addition of CEUS revealed perfusion defects after 4 h. This might facilitate detection and characterization of perfusion defects in transplanted livers.

引用

页码：475 / 482

页数：8

共 28 条

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