Construction of Optically Active Indolines by Formal [4+1] Annulation of Sulfur Ylides and N-(ortho-Chloromethyl)aryl Amides

被引：96
作者：
Yang, Qing-Qing [1 ]
Wang, Qiang [1 ]
An, Jing [1 ]
Chen, Jia-Rong [1 ]
Lu, Liang-Qiu [1 ]
Xiao, Wen-Jing [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 26期
基金：
美国国家科学基金会;
关键词：
annulation; asymmetric synthesis; cascade reaction; indolines; sulfur ylides; CATALYZED ASYMMETRIC HYDROGENATION; HIGHLY ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; CASCADE REACTIONS; HETEROCYCLIC ARCHITECTURES; ALKENE HYDROAMINATION; CARBONYL-COMPOUNDS; SULFOXONIUM YLIDE; MICHAEL ADDITION; TANDEM REACTIONS;
D O I：
10.1002/chem.201300988
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Get asymmetric! Asymmetric [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides allowed the formation of the desired cycloadduct with moderate to high yields and enantioselectivities (see scheme). The described strategy, taking advantage of chiral sulfur ylides, represents a direct procedure to access chiral 2-substituted indolines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8401 / 8404
页数：4
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