Integrins and metastasis

被引：171
作者：
Ganguly, Kirat Kumar [1 ]
Pal, Sekhar [1 ]
Moulik, Shuvojit [1 ]
Chatterjee, Amitava [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Receptor Biol & Tumor Metastasis, Kolkata, India
来源：
CELL ADHESION & MIGRATION | 2013年 / 7卷 / 03期
关键词：
integrin; metastasis; MMP; invasion; adhesion; HUMAN BREAST-CANCER; HUMANIZED MONOCLONAL-ANTIBODY; GENE-EXPRESSION SIGNATURE; CIRCULATING TUMOR-CELLS; ADVANCED SOLID TUMORS; PHASE-I; ALPHA(V)BETA(3) INTEGRIN; ALPHA(5)BETA(1) INTEGRIN; MATRIX METALLOPROTEINASES; EXTRACELLULAR SEGMENT;
D O I：
10.4161/cam.23840
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and detachment, which recruit integrin receptors in this flow of events. World literatures show several aspects of interrelation of integrins and metastasis. Integrin molecules are being used as prime target to battle metastasis. In this review we are collating the observations showing importance of integrin biology in regulation of metastasis and the strategies where integrin receptors are being used as targets to regulate metastasis.
引用
收藏
页码：251 / 261
页数：11
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