Human gut microbiota community structures in urban and rural populations in Russia

被引：193

作者：

Tyakht, Alexander V. ^{[1
]}

Kostryukova, Elena S. ^{[1
]}

Popenko, Anna S. ^{[1
]}

Belenikin, Maxim S. ^{[1
]}

Pavlenko, Alexander V. ^{[1
]}

Larin, Andrey K. ^{[1
]}

Karpova, Irina Y. ^{[1
]}

Selezneva, Oksana V. ^{[1
]}

Semashko, Tatyana A. ^{[1
]}

Ospanova, Elena A. ^{[1
]}

Babenko, Vladislav V. ^{[1
]}

Maev, Igor V. ^{[2
]}

Cheremushkin, Sergey V. ^{[2
]}

Kucheryavyy, Yuriy A. ^{[2
]}

Shcherbakov, Petr L. ^{[3
]}

Grinevich, Vladimir B. ^{[4
]}

Efimov, Oleg I. ^{[4
]}

Sas, Evgenii I. ^{[4
]}

Abdulkhakov, Rustam A. ^{[5
]}

Abdulkhakov, Sayar R. ^{[6
]}

Lyalyukova, Elena A. ^{[7
]}

Livzan, Maria A. ^{[7
]}

Vlassov, Valentin V. ^{[8
]}

Sagdeev, Renad Z. ^{[9
]}

Tsukanov, Vladislav V. ^{[10
]}

Osipenko, Marina F. ^{[11
]}

Kozlova, Irina V. ^{[12
]}

Tkachev, Alexander V. ^{[13
]}

Sergienko, Valery I. ^{[1
]}

Alexeev, Dmitry G. ^{[14
]}

Govorun, Vadim M. ^{[1
,14
,15
]}

机构：

[1] Res Inst Physicochem Med, Moscow 119435, Russia

[2] Moscow State Univ Med & Dent, Dept Internal Dis Propedeut & Gastroenterol, Moscow 127473, Russia

[3] Cent Sci Inst Gastroenterol, Moscow 111123, Russia

[4] Kirov Mil Med Acad, St Petersburg 194175, Russia

[5] Kazan State Med Univ, Dept Hosp Therapy, Kazan 420012, Russia

[6] Kazan Volga Reg Fed Univ, Dept Human Anat, Kazan 420008, Russia

[7] Omsk State Med Acad, Omsk 644043, Russia

[8] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia

[9] Russian Acad Sci, Siberian Branch, Int Tomog Ctr, Novosibirsk 630090, Russia

[10] Sci Res Inst Med Problems North, Krasnoyarsk 660022, Russia

[11] Novosibirsk State Med Univ, Dept Internal Dis Propedeut, Novosibirsk 630091, Russia

[12] Saratov State Med Univ, Dept Therapy, Saratov 410012, Russia

[13] Rostov State Med Univ, Dept Internal Dis Propedeut, Rostov Na Donu 344022, Russia

[14] Moscow Inst Phys & Technol, Dolgoprudnyi 141700, Russia

[15] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

关键词：

RESISTANT STARCH; ALIGNMENT; DIET; DEGRADATION; PACKAGE; IMPACT; DNA;

D O I：

10.1038/ncomms3469

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing has delineated the structural and functional configurations of gut metagenomes in world populations. The microbiota of the Russian population is of particular interest to researchers, because Russia encompasses a uniquely wide range of environmental conditions and ethnogeographical cohorts. Here we conduct a shotgun metagenomic analysis of gut microbiota samples from 96 healthy Russian adult subjects, which reveals novel microbial community structures. The communities from several rural regions display similarities within each region and are dominated by the bacterial taxa associated with the healthy gut. Functional analysis shows that the metabolic pathways exhibiting differential abundance in the novel types are primarily associated with the trade-off between the Bacteroidetes and Firmicutes phyla. The specific signatures of the Russian gut microbiota are likely linked to the host diet, cultural habits and socioeconomic status.

引用

页数：9

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