Platinum-catalyzed asymmetric alkylation of secondary phosphines: Enantioselective synthesis of P-stereogenic phosphines

被引：178
作者：
Scriban, C [1 ]
Glueck, DS [1 ]
机构：
[1] Dartmouth Coll, Dept Chem, Burke Lab 6128, Hanover, NH 03755 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 09期
关键词：
D O I：
10.1021/ja058096q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chiral Pt catalyst precursor Pt((R,R)-Me-Duphos)(Ph)(Cl) mediated alkylation of racemic secondary phosphines PHR(R′) with benzyl halides in the presence of base to give enantioenriched tertiary phosphines PR(R′)(CH2Ar). Similar reactions of bis(secondary) phosphines yielded chiral diphosphines in up to 93% ee and with good rac/meso diastereoselection. Copyright © 2006 American Chemical Society.
引用
收藏
页码：2788 / 2789
页数：2
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