The hallmarks of cancer are also the hallmarks of wound healing

被引：112
作者：
MacCarthy-Morrogh, Lucy [1 ]
Martin, Paul [1 ,2 ,3 ]
机构：
[1] Univ Bristol, Sch Biochem, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England
[2] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England
[3] Cardiff Univ, Sch Med, Cardiff CF14 4XN, Wales
来源：
SCIENCE SIGNALING | 2020年 / 13卷 / 648期
基金：
英国惠康基金;
关键词：
ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; MOLECULAR-MECHANISMS; TGF-BETA; INFLAMMATORY RESPONSE; TISSUE REGENERATION; SUPPRESSOR-CELLS; CARCINOMA-CELLS; T-CELLS; REPAIR;
D O I：
10.1126/scisignal.aay8690
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Hanahan and Weinberg "hallmarks of cancer" papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.
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页数：12
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