The hallmarks of cancer are also the hallmarks of wound healing

被引：112
作者：
MacCarthy-Morrogh, Lucy [1 ]
Martin, Paul [1 ,2 ,3 ]
机构：
[1] Univ Bristol, Sch Biochem, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England
[2] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England
[3] Cardiff Univ, Sch Med, Cardiff CF14 4XN, Wales
来源：
SCIENCE SIGNALING | 2020年 / 13卷 / 648期
基金：
英国惠康基金;
关键词：
ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; MOLECULAR-MECHANISMS; TGF-BETA; INFLAMMATORY RESPONSE; TISSUE REGENERATION; SUPPRESSOR-CELLS; CARCINOMA-CELLS; T-CELLS; REPAIR;
D O I：
10.1126/scisignal.aay8690
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Hanahan and Weinberg "hallmarks of cancer" papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.
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页数：12
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共 178 条
[121]   Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer [J].
Ostrand-Rosenberg, Suzanne ;
Sinha, Pratima .
JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :4499-4506
[122]   Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice [J].
Park, Sangbum ;
Gonzalez, David G. ;
Guirao, Boris ;
Boucher, Jonathan D. ;
Cockburn, Katie ;
Marsh, Edward D. ;
Mesa, Kailin R. ;
Brown, Samara ;
Rompolas, Panteleimon ;
Haberman, Ann M. ;
Bellaiche, Yohanns ;
Greco, Valentina .
NATURE CELL BIOLOGY, 2017, 19 (03) :155-163
[123]   Tensional homeostasis and the malignant phenotype [J].
Paszek, MJ ;
Zahir, N ;
Johnson, KR ;
Lakins, JN ;
Rozenberg, GI ;
Gefen, A ;
Reinhart-King, CA ;
Margulies, SS ;
Dembo, M ;
Boettiger, D ;
Hammer, DA ;
Weaver, VM .
CANCER CELL, 2005, 8 (03) :241-254
[124]   Multiple transcription factor codes activate epidermal wound-response genes in Drosophila [J].
Pearson, Joseph C. ;
Juarez, Michelle T. ;
Kim, Myungjin ;
McGinnis, William .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2224-2229
[125]   Mechanosensitive ion channels push cancer progression [J].
Petho, Zoltan ;
Najder, Karolina ;
Bulk, Etmar ;
Schwab, Albrecht .
CELL CALCIUM, 2019, 80 :79-90
[126]   Mechanisms of BCG immunotherapy and its outlook for bladder cancer [J].
Pettenati, Caroline ;
Ingersoll, Molly A. .
NATURE REVIEWS UROLOGY, 2018, 15 (10) :615-625
[127]   Mutational signature in colorectal cancer caused by genotoxic pks+E. coli [J].
Pleguezuelos-Manzano, Cayetano ;
Puschhof, Jens ;
Huber, Axel Rosendahl ;
van Hoeck, Arne ;
Wood, Henry M. ;
Nomburg, Jason ;
Gurjao, Carino ;
Manders, Freek ;
Dalmasso, Guillaume ;
Stege, Paul B. ;
Paganelli, Fernanda L. ;
Geurts, Maarten H. ;
Beumer, Joep ;
Mizutani, Tomohiro ;
Miao, Yi ;
van der Linden, Reinier ;
van der Elst, Stefan ;
Garcia, K. Christopher ;
Top, Janetta ;
Willems, Rob J. L. ;
Giannakis, Marios ;
Bonnet, Richard ;
Quirke, Phil ;
Meyerson, Matthew ;
Cuppen, Edwin ;
van Boxtel, Ruben ;
Clevers, Hans .
NATURE, 2020, 580 (7802) :269-+
[128]   Regeneration of fat cells from myofibroblasts during wound healing [J].
Plikus, Maksim V. ;
Guerrero-Juarez, Christian F. ;
Ito, Mayumi ;
Li, Yun Rose ;
Dedhia, Priya H. ;
Zheng, Ying ;
Shao, Mengle ;
Gay, Denise L. ;
Ramos, Raul ;
Hsi, Tsai-Ching ;
Oh, Ji Won ;
Wang, Xiaojie ;
Ramirez, Amanda ;
Konopelski, Sara E. ;
Elzein, Arijh ;
Wang, Anne ;
Supapannachart, Rarinthip June ;
Lee, Hye-Lim ;
Lim, Chae Ho ;
Nace, Arben ;
Guo, Amy ;
Treffeisen, Elsa ;
Andl, Thomas ;
Ramirez, Ricardo N. ;
Murad, Rabi ;
Offermanns, Stefan ;
Metzger, Daniel ;
Chambon, Pierre ;
Widgerow, Alan D. ;
Tuan, Tai-Lan ;
Mortazavi, Ali ;
Gupta, Rana K. ;
Hamilton, Bruce A. ;
Millar, Sarah E. ;
Seale, Patrick ;
Pear, Warren S. ;
Lazar, Mitchell A. ;
Cotsarelis, George .
SCIENCE, 2017, 355 (6326) :748-+
[129]   Pirfenidone normalizes the tumor microenvironment to improve chemotherapy [J].
Polydorou, Christiana ;
Mpekris, Fotios ;
Papageorgis, Panagiotis ;
Voutouri, Chrysovalantis ;
Stylianopoulos, Triantafyllos .
ONCOTARGET, 2017, 8 (15) :24506-24517
[130]   TGF-β: Duality of Function Between Tumor Prevention and Carcinogenesis [J].
Principe, Daniel R. ;
Doll, Jennifer A. ;
Bauer, Jessica ;
Jung, Barbara ;
Munshi, Hidayatullah G. ;
Bartholin, Laurent ;
Pasche, Boris ;
Lee, Chung ;
Grippo, Paul J. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (02)
891011121314151617