Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism-Review

被引：32

作者：

Daniel, Trnka ^{[1
]}

Faruq, Hossain Md ^{[1
]}

Magdalena, Jordt Laura ^{[1
]}

Manuela, Gellert ^{[1
]}

Horst, Lillig Christopher ^{[2
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Univ Med, Inst Med Biochem & Mol Biol, D-17475 Greifswald, Germany

[2] Univ Med Greifswald, Christopher Horst Lillig Inst Med Biochem & Mol B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany

来源：

MOLECULES | 2020年 / 25卷 / 17期

关键词：

glutathione; glutaredoxin; iron-sulfur cluster; iron; LINKED SIDEROBLASTIC ANEMIA; MONOTHIOL GLUTAREDOXINS; PROTEIN BIOGENESIS; SCAFFOLD PROTEINS; REDOX REGULATION; CLUSTER TRANSFER; 2FE-2S CLUSTER; MOLECULAR-MECHANISMS; CARDIAC-HYPERTROPHY; EXPRESSION PATTERN;

D O I：

10.3390/molecules25173860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathione (GSH) was initially identified and characterized for its redox properties and later for its contributions to detoxification reactions. Over the past decade, however, the essential contributions of glutathione to cellular iron metabolism have come more and more into focus. GSH is indispensable in mitochondrial iron-sulfur (FeS) cluster biosynthesis, primarily by co-ligating FeS clusters as a cofactor of the CGFS-type (class II) glutaredoxins (Grxs). GSH is required for the export of the yet to be defined FeS precursor from the mitochondria to the cytosol. In the cytosol, it is an essential cofactor, again of the multi-domain CGFS-type Grxs, master players in cellular iron and FeS trafficking. In this review, we summarize the recent advances and progress in this field. The most urgent open questions are discussed, such as the role of GSH in the export of FeS precursors from mitochondria, the physiological roles of the CGFS-type Grx interactions with BolA-like proteins and the cluster transfer between Grxs and recipient proteins.

引用

页数：26

共 173 条

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