EEG Spectral Analysis in Primary Insomnia: NREM Period Effects and Sex Differences

被引:128
作者
Buysse, Daniel J. [1 ,2 ]
Germain, Anne [1 ,2 ]
Hall, Martica L. [1 ,2 ]
Moul, Douglas E. [3 ]
Nofzinger, Eric A. [1 ,2 ]
Begley, Amy [1 ,2 ]
Ehlers, Cindy L. [4 ]
Thompson, Wesley [1 ,2 ,5 ]
Kupfer, David J. [1 ,2 ]
机构
[1] Univ Pittsburgh, Sch Med, Neurosci Clin & Translat Res Ctr, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Sleep Med Inst, Pittsburgh, PA USA
[3] Louisiana State Univ, Dept Psychiat, Shreveport, LA 71105 USA
[4] Scripps Res Inst, La Jolla, CA USA
[5] Univ Pittsburgh, Dept Stat, Pittsburgh, PA USA
关键词
Insomnia; non-rapid eye movement sleep; power spectral analysis; primary insomnia; sleep; electroencephalogram (EEG);
D O I
10.1093/sleep/31.12.1673
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep. Design: Overnight polysomnographic study. Setting: Sleep laboratory. Participants: PI (n = 48; 29 women) and GSC (n = 25; 15 women). Interventions: None. Measurements: EEG power from 1-50 Hz was computed for artifact-free sleep epochs across four NREM periods. Repeated measures mixed effect models contrasted differences between groups, EEG frequency bands, and NREM periods. EEG power-frequency curves were modeled using regressions with fixed knot splines. Results: Mixed models showed no significant group (PI vs. GSC) differences; marginal sex differences (delta and theta bands); significant differences across NREM periods; and group*sex and group*NREM period interactions, particularly in beta and gamma bands. Modeled power-frequency curves showed no group difference in whole-night NREM, but PI had higher power than GSC from 18-40 Hz in the first NREM period. Among women, PI had higher 16 to 44-Hz power than GSC in the first 3 NREM periods, and higher 3 to 5-Hz power across all NREM periods. PI and GSC men showed no consistent differences in EEG power. High-frequency EEG power was not related to clinical or subjective sleep ratings in PI. Conclusions: Women with PI, but not men, showed increased high-frequency and low-frequency EEG activity during NREM sleep compared to GSC, particularly in early NREM periods. Sex and NREM period may moderate quantitative EEG differences between PI and GSC.
引用
收藏
页码:1673 / 1682
页数:10
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