Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

被引：133

作者：

Aulchenko, Yurii S. ^{[2
]}

Hoppenbrouwers, Ilse A. ^{[1
]}

Ramagopalan, Sreeram V. ^{[3
,4
]}

Broer, Linda ^{[1
,2
]}

Jafari, Naghmeh ^{[1
]}

Hillert, Jan ^{[5
]}

Link, Jenny ^{[5
]}

Lundstrom, Wangko ^{[5
]}

Greiner, Eva ^{[5
]}

Sadovnick, A. Dessa ^{[6
]}

Goossens, Dirk ^{[7
,8
,9
]}

Van Broeckhoven, Christine ^{[7
,8
,9
]}

Del-Favero, Jurgen ^{[7
,8
,9
]}

Ebers, George C. ^{[3
,4
]}

Oostra, Ben A. ^{[2
]}

van Duijn, Cornelia M. ^{[2
]}

Hintzen, Rogier Q. ^{[1
]}

机构：

[1] Erasmus MC, MS Ctr ErasMS, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol & Biostat & Clin Genet, Genet Epidemiol Unit, NL-3000 CA Rotterdam, Netherlands

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 9DU, England

[4] Univ Oxford, Dept Clin Neurol, Oxford OX3 9DU, England

[5] Karolinska Inst, Dept Neurol, SE-14186 Stockholm, Sweden

[6] Univ British Columbia, Dept Med Genet, Div Neurol, Vancouver, BC V6T 2B5, Canada

[7] VIB, Dept Mol Genet, Appl Mol Genom Grp, B-2610 Antwerp, Belgium

[8] VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

[9] Univ Antwerp, B-2610 Antwerp, Belgium

来源：

NATURE GENETICS | 2008年 / 40卷 / 12期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1038/ng.251

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

引用

页码：1402 / 1403

页数：2

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