Tandem Suzuki-Miyaura Coupling/Acid-Catalyzed Cyclization between Vinyl Ether Boronates and Vinyl Halides: A Concise Approach to Polysubstituted Furans

被引：24

作者：

Butkevich, Alexey N. ^{[1
]}

Meerpoel, Lieven ^{[3
]}

Stansfield, Ian ^{[2
]}

Angibaud, Patrick ^{[2
]}

Corbu, Andrei ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] ESPCI ParisTech, CNRS, Chim Organ Lab, F-75231 Paris 05, France

[2] Janssen Res & Dev, Oncol & Med Chem, F-27106 Val De Reuil, France

[3] Janssen Res & Dev, B-2340 Beerse, Belgium

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 15期

关键词：

MULTISUBSTITUTED 2-ACYL FURANS; ONE-POT SYNTHESIS; SUBSTITUTED FURANS; EFFICIENT SYNTHESIS; DERIVATIVES; 1,6-DIOXASPIRO<4.5>DEC-3-ENES; CIS-2-EN-4-YN-1-OLS; SPIROACETALS; ROUTE; ACID;

D O I：

10.1021/ol4014574

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polysubstituted 2-(omega-hydroxyalkyl)furans were prepared by tandem Suzuki-Miyaura coupling/acid-catalyzed cyclization starting from appropriately substituted 3-haloallylic alcohols and dihydrofuran-, dihydropyran- or glycal-derived pinacol boronates.

引用

页码：3840 / 3843

页数：4

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