β-Cyclodextrin Incorporated Carbon Nanotube Paste Electrode as Electrochemical Sensor for Nifedipine

被引：34
作者：
Kor, Kamalodin [1 ]
Zarei, Kobra [1 ]
机构：
[1] Damghan Univ, Sch Chem, Damghan, Iran
来源：
ELECTROANALYSIS | 2013年 / 25卷 / 06期
关键词：
-Cyclodextrin; Differential pulse voltammetry; Multiwalled-carbon nanotubes paste electrode; Nifedipine; GUEST RECOGNITION APPROACH; INCLUSION COMPLEX; COATED ELECTRODE; PHARMACEUTICAL FORMULATIONS; ELECTROCATALYTIC OXIDATION; VOLTAMMETRIC DETERMINATION; URINE; DNA; NOREPINEPHRINE; DOPAMINE;
D O I：
10.1002/elan.201200652
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this work a carbon paste electrode modified with multiwalled carbon nanotubes/-cyclodextrin (MWCNTs/-CD) was constructed and applied to the determination of nifedipine. The electrochemical behavior of nifedipine at this electrode was investigated using cyclic voltammetry and differential pulse voltammetry. Characterization of the modified electrode was conducted with electrochemical impedance spectroscopy and scanning electron microscopy. After adsorption of nifedipine on the MWCNTs/-CD paste electrode at 0.0V for 6min, a well defined reduction peak was produced in sodium hydroxide of 0.05M. The calibration curve was linear from 7.0x10-8 to 1.5x10-5M. The detection limit was obtained as 2.5x10-8M. The results demonstrated that this electrochemical sensor has excellent sensitivity and selectivity. This sensor was applied for determination of nifedipine in drug dosage and blood serum with excellent recoveries.
引用
收藏
页码：1497 / 1504
页数：8
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