Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

被引:153
作者
Eklund, Lauri [1 ,2 ]
Kangas, Jaakko [1 ,2 ]
Saharinen, Pipsa [3 ,4 ]
机构
[1] Oulu Ctr Cell Matrix Res, Fac Biochem & Mol Med, Aapistie 5A, FI-90014 Oulu, Finland
[2] Bioctr Oulu, Aapistie 5A, FI-90014 Oulu, Finland
[3] Univ Helsinki, Res Programs Unit, Translat Canc Biol Program, Haartmaninkatu 8,POB 63, FI-00014 Helsinki, Finland
[4] Wihuri Res Inst, Biomedicum Helsinki, Haartmaninkatu 8,POB 63, FI-00014 Helsinki, Finland
基金
芬兰科学院;
关键词
angiogenesis; angiopoietin; Angpt; Ang1; Ang2; cardiovascular disease; lymphangiogenesis; Tie1; Tie2; TEK; VE-PTP; integrin; RECEPTOR-TYROSINE KINASE; PHOSPHATASE VE-PTP; HEMATOPOIETIC PROGENITOR CELLS; MULTIPLE-ORGAN DYSFUNCTION; VASCULAR ENDOTHELIAL-CELLS; INHIBITS TUMOR-GROWTH; PERMEABILITY IN-VIVO; VESSEL DEVELOPMENT; DIABETIC-RETINOPATHY; BLOOD-VESSELS;
D O I
10.1042/CS20160129
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Endothelial cells that form the inner layer of blood and lymphatic vessels are important regulators of vascular functions and centrally involved in the pathogenesis of vascular diseases. In addition to the vascular endothelial growth factor (VEGF) receptor pathway, the angiopoietin (Ang)-Tie system is a second endothelial cell specific ligand-receptor signalling system necessary for embryonic cardiovascular and lymphatic development. The Ang-Tie system also regulates postnatal angiogenesis, vessel remodelling, vascular permeability and inflammation to maintain vascular homoeostasis in adult physiology. This system is implicated in numerous diseases where the vasculature has an important contribution, such as cancer, sepsis, diabetes, atherosclerosis and ocular diseases. Furthermore, mutations in the TIE2 signalling pathway cause defects in vascular morphogenesis, resulting in venous malformations and primary congenital glaucoma. Here, we review recent advances in the understanding of the Ang-Tie signalling system, including cross-talk with the vascular endothelial protein tyrosine phosphatase (VE-PTP) and the integrin cell adhesion receptors, focusing on the Ang-Tie system in vascular development and pathogenesis of vascular diseases.
引用
收藏
页码:87 / 103
页数:17
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