共 28 条
Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
被引:42
作者:

Long, Jianwen
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h-index: 0
机构:
Hubei Prov Acad Tradit Chinese Med, Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan 430061, Peoples R China
Hubei Univ Chinese Med, Clin Sch 1, Dept Dermatol, Wuhan 430061, Peoples R China Hubei Prov Acad Tradit Chinese Med, Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan 430061, Peoples R China

Pi, Xianming
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h-index: 0
机构:
Hubei Prov Acad Tradit Chinese Med, Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan 430061, Peoples R China Hubei Prov Acad Tradit Chinese Med, Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan 430061, Peoples R China
机构:
[1] Hubei Prov Acad Tradit Chinese Med, Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan 430061, Peoples R China
[2] Hubei Univ Chinese Med, Clin Sch 1, Dept Dermatol, Wuhan 430061, Peoples R China
关键词:
CANCER;
PHOSPHORYLATION;
PROLIFERATION;
ACTIVATION;
D O I:
10.1155/2020/5149417
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
To investigate whether Polyphyllin I (PPI) might induce the autophagy and apoptosis of melanoma cells by regulating PI3K/Akt/mTOR signal pathway. Melanoma A375 cells were incubated with different concentrations of Polyphyllin I (0, 1.5, 3.0, and 6.0 mg/L) and PI3K/Akt/mTOR signaling pathway activator IGF-1(20 mg/L). CCK-8 assay was utilized to detect cell proliferation; Cell apoptosis and cell cycle were measured by flow cytometry; Western blot was used to examine the expressions of proteins. Immunofluorescence analysis was performed to evaluate autophagy of A375 cells; In addition, xenograft-bearing nude mice were applied to study the role of Polyphyllin I on melanoma development, melanoma cell proliferation, as well as melanoma cell apoptosis in vivo. The outcomes represented that Polyphyllin I promoted A375 cell apoptosis via upregulating Bax level and cleaved caspase-3 level and downregulating Bcl-2 level, inhibited the growth of A375 cells at the G0/G1 phase, and enhanced cell autophagy via regulating the levels of Beclin 1, LC3II, and p62. However, IGF-1 (an activator of PI3K/Akt/mTOR signal pathway) attenuated these changes that Polyphyllin I induced. Furthermore, the xenograft model experiment confirmed that Polyphyllin I treatment suppressed xenograft tumor growth, increased apoptotic index evaluated by the TUNEL method, and reduced the level of Ki67 in tumor tissues in vivo. In conclusion, Polyphyllin I treatment enhanced melanoma cell autophagy and apoptosis, as well as blocked melanoma cell cycle via suppressing PI3K/Akt/mTOR signal pathway. Meanwhile, Polyphyllin I treatment suppressed the development of melanoma in vivo. Therefore, Polyphyllin I possibly is a promising molecular targeted agent used in melanoma therapy.
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共 28 条
[1]
Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
[J].
Butler, Dominika E.
;
Marlein, Christopher
;
Walker, Hannah F.
;
Frame, Fiona M.
;
Mann, Vincent M.
;
Simms, Matthew S.
;
Davies, Barry R.
;
Collins, Anne T.
;
Maitland, Norman J.
.
ONCOTARGET,
2017, 8 (34)
:56698-56713

Butler, Dominika E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Marlein, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Univ East Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Walker, Hannah F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Frame, Fiona M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Mann, Vincent M.
论文数: 0 引用数: 0
h-index: 0
机构:
Hull Royal Infirm, Gastroenterol Res Dept, Kingston Upon Hull HU3 2JZ, N Humberside, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Simms, Matthew S.
论文数: 0 引用数: 0
h-index: 0
机构:
Hull & E Yorkshire Hosp NHS Trust, Castle Hill Hosp, Dept Urol, Cottingham HU16 5JQ, England
Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Davies, Barry R.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Cambridge Inst, AstraZeneca, Cambridge CB2 0RE, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Collins, Anne T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England

Maitland, Norman J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England Univ York, Dept Biol, Canc Res Unit, York YO10 5DD, N Yorkshire, England
[2]
Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo
[J].
Chang, Junli
;
Li, Yimian
;
Wang, Xianyang
;
Hu, Shaopu
;
Wang, Hongshen
;
Shi, Qi
;
Wang, Yongjun
;
Yang, Yanping
.
SCIENTIFIC REPORTS,
2017, 7

Chang, Junli
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Li, Yimian
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Wang, Xianyang
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Hu, Shaopu
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Wang, Hongshen
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Shi, Qi
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Wang, Yongjun
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

Yang, Yanping
论文数: 0 引用数: 0
h-index: 0
机构:
Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
Shanghai Univ Tradit Chinese Med, Spine Inst, Shanghai 200032, Peoples R China
Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
[3]
Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells
[J].
Che, Song-Tian
;
Bie, Li
;
Li, Xu
;
Qi, Hui
;
Yu, Peng
;
Zuo, Ling
.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,
2019, 12 (10)
:1531-1538

Che, Song-Tian
论文数: 0 引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China

Bie, Li
论文数: 0 引用数: 0
h-index: 0
机构:
First Hosp Jilin Univ, Dept Neurosurg, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China

Li, Xu
论文数: 0 引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China

Qi, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China

Yu, Peng
论文数: 0 引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China

Zuo, Ling
论文数: 0 引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China Second Hosp Jilin Univ, Dept Ocular Fundus Dis, 218 Ziqiang St, Changchun 130022, Jilin, Peoples R China
[4]
Methylwogonin exerts anticancer effects in A375 human malignant melanoma cells through apoptosis induction, DNA damage, cell invasion inhibition and downregulation of the mTOR/PI3K/Akt signalling pathway
[J].
Chen, Jiaorong
;
Huang, Chunmei
;
Liu, Fangfang
;
Xu, Zihui
;
Li, Li
;
Huang, Zheng
;
Zhang, Hongfeng
.
ARCHIVES OF MEDICAL SCIENCE,
2019, 15 (04)
:1056-1064

Chen, Jiaorong
论文数: 0 引用数: 0
h-index: 0
机构:
Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Huang, Chunmei
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Pathol Dept, Wuhan 430014, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Liu, Fangfang
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Pathol Dept, Wuhan 430014, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Xu, Zihui
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Endocrinol Dept, Wuhan, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Li, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Pathol Dept, Wuhan 430014, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Huang, Zheng
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Pathol Dept, Wuhan 430014, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China

Zhang, Hongfeng
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Pathol Dept, Wuhan 430014, Hubei, Peoples R China Hubei Univ Tradit Chinese Med, Basic Med Coll, Dept Anat & Histol & Embryol, Wuhan, Hubei, Peoples R China
[5]
Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)
[J].
Dan, Han C.
;
Ebbs, Aaron
;
Pasparakis, Manolis
;
Van Dyke, Terry
;
Basseres, Daniela S.
;
Baldwin, Albert S.
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2014, 289 (36)
:25227-25240

Dan, Han C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA
Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA

Ebbs, Aaron
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA

Pasparakis, Manolis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cologne, Inst Genet, Cologne, Germany Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA

Van Dyke, Terry
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA

Basseres, Daniela S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA

Baldwin, Albert S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA
[6]
Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM in vitro
[J].
Gu, Linhui
;
Feng, Jianguo
;
Xu, Haiyan
;
Luo, Min
;
Su, Dan
.
JOURNAL OF TRADITIONAL CHINESE MEDICINE,
2013, 33 (03)
:325-333

Gu, Linhui
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China

Feng, Jianguo
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China

Xu, Haiyan
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China

Luo, Min
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China

Su, Dan
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310022, Zhejiang, Peoples R China
[7]
Role of autophagy in cancer - Management of metabolic stress
[J].
Jin, Shengkan
;
White, Eileen
.
AUTOPHAGY,
2007, 3 (01)
:28-31

Jin, Shengkan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA

White, Eileen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA
[8]
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
[J].
Kim, Joungmok
;
Kundu, Mondira
;
Viollet, Benoit
;
Guan, Kun-Liang
.
NATURE CELL BIOLOGY,
2011, 13 (02)
:132-U71

Kim, Joungmok
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92130 USA Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA

Kundu, Mondira
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA

Viollet, Benoit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, INSERM, Inst Cochin, CNRS,UMR 8104,U1016, Paris, France Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA

Guan, Kun-Liang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92130 USA Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92130 USA
[9]
Targeting autophagy in cancer
[J].
Levy, Jean M. Mulcahy
;
Towers, Christina G.
;
Thorburn, Andrew
.
NATURE REVIEWS CANCER,
2017, 17 (09)
:528-542

Levy, Jean M. Mulcahy
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn, Pediat Brain Tumor Res Program, Aurora, CO 80045 USA
Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

Towers, Christina G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

Thorburn, Andrew
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA
[10]
Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells
[J].
Luo, Qihui
;
Yang, Dandan
;
Qi, Qi
;
Huang, Chao
;
Chen, Bing
;
Liu, Wentao
;
Shi, Liangqin
;
Xia, Yu
;
Tang, Li
;
Fang, Jing
;
Ou, Yangping
;
Geng, Yi
;
Chen, Zhengli
.
BIOMED RESEARCH INTERNATIONAL,
2018, 2018

Luo, Qihui
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Yang, Dandan
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Qi, Qi
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Huang, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Chen, Bing
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Liu, Wentao
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Shi, Liangqin
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Xia, Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Tang, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
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Fang, Jing
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Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Ou, Yangping
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Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Geng, Yi
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Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China
Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

Chen, Zhengli
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Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China Sichuan Agr Univ, Coll Vet Med, Lab Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China