Iridoid constituents from the male flower of Eucommia ulmoides and their promotion proliferation on ESF-1

被引：15

作者：

Ding, Yan-Xia ^{[1
]}

Li, Qin ^{[2
]}

Zhang, Huan ^{[2
]}

Kim, Young-Ho ^{[3
]}

Dou, De-Qiang ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

[2] Henan Univ, Henan Prov Lab Eucommia Ulmoides Cultivat & Utili, Kaifeng 475001, Peoples R China

[3] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 09期

关键词：

Eucommia ulmoides; iridoids; promotion proliferation; ESF-1; PEDICULARIS-ARTSELAERI; CHEMICAL-CONSTITUENTS; GREEN LEAVES; GLYCOSIDES; OLIV;

D O I：

10.1080/10286020.2015.1039999

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new iridoids (1, 2, 12, and 13), together with nine known iridoids (3-11), were isolated from the male flowers of Eucommia ulmoides Oliver and were characterized as 3-methoxyartselawnin C (1), 6-hydroxyl-1,3-dimethoxyartsclaenin III (2), 3,4-dihydro-3-ethoxyasperuloside (12) and 3,4-dihydro-3-ethoxydesacetylasperuloside (13) by extensive analyses of their 1D and 2D NMR spectroscopy and mass spectra. All of the isolated compounds were assayed for the promoting proliferation of skin fibroblasts cell (ESF-1) and compounds 4 and 7 (5M) significantly stimulated the proliferation of ESF-1 cells.

引用

页码：867 / 875

页数：9

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