Immunity around the clock

被引：233

作者：

Man, Kevin ^{[1
]}

Loudon, Andrew ^{[2
]}

Chawla, Ajay ^{[1
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[2] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

SCIENCE | 2016年 / 354卷 / 6315期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

INNATE LYMPHOID-CELLS; CIRCADIAN CLOCK; DIURNAL OSCILLATIONS; DIFFERENTIATION; ALPHA; NFIL3; SUSCEPTIBILITY; MACROPHAGES; METABOLISM; EXPRESSION;

D O I：

10.1126/science.aah4966

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli but whose overactivation can result in immunopathologies and sometimes even death. Because many immune parameters oscillate rhythmically with the time of day, the circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which, in turn, enhances organismal fitness. This is mediated by interactions between extrinsic environmental cues and the intrinsic oscillators of immune cells, which together optimize immune responses throughout the circadian cycle. The elucidation of these clock-controlled immunomodulatory mechanisms might uncover new approaches for treating infections and chronic inflammatory diseases.

引用

页码：999 / 1003

页数：5

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