Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

被引：10

作者：

Rezaei, Zahra ^{[1
,2
]}

Yilmaz-Aykut, Dilara ^{[1
,3
]}

Tourk, Fatima Mumtaza ^{[1
,4
]}

Bassous, Nicole ^{[1
]}

Barroso-Zuppa, Margot ^{[1
,5
]}

Shawl, Asif Iqbal ^{[6
]}

Ashraf, Syed Salman ^{[6
,7
,8
,9
]}

Avci, Huseyin ^{[10
,11
,12
]}

Hassan, Shabir ^{[1
,6
,9
]}

机构：

[1] Harvard Med Sch, Div Engn Med, Brigham & Womens Hosp, Dept Med, Cambridge, MA 02139 USA

[2] Sharif Univ Technol, Chem Engn Dept, Azadi Ave, Tehran 1136511155, Iran

[3] Istanbul Univ Cerrahpasa, Fac Engn, Dept Chem Engn, TR-34320 Istanbul, Turkey

[4] Northeastern Univ, Dept Mech Engn, Boston, MA 02115 USA

[5] Tecnol Monterrey, Sch Med & Hlth Sci, Mexico City 14380, DF, Mexico

[6] Khalifa Univ, Coll Arts & Sci, Dept Biol, Main Campus,POB 127788, Abu Dhabi, U Arab Emirates

[7] Khalifa Univ, Ctr Biotechnol BTC, Main Campus,POB 127788, Abu Dhabi, U Arab Emirates

[8] Khalifa Univ, Ctr Catalysis & Separat CeCas, SAN Campus,POB 127788, Abu Dhabi, U Arab Emirates

[9] Khalifa Univ, Adv Mat Chem Ctr AMCC, SAN Campus,POB 127788, Abu Dhabi, U Arab Emirates

[10] Eskisehir Osmangazi Univ, Dept Met & Mat Engn, TR-26040 Eskisehir, Turkey

[11] Eskisehir Osmangazi Univ, Cellular Therapy & Stem Cell Res Ctr, TR-26040 Eskisehir, Turkey

[12] Eskisehir Osmangazi Univ, Translat Med Res & Clin Ctr, TR-26040 Eskisehir, Turkey

来源：

PHARMACEUTICS | 2022年 / 14卷 / 10期

关键词：

hydrogels; immune modulation; biomaterials; foreign body response; tissue engineering; REGULATORY T-CELLS; IMMUNE MODULATION; BIOMATERIALS; ANTIGEN; CANCER; ACID; IMMUNOTHERAPY; MACROPHAGES; PERFORMANCE; STRATEGIES;

D O I：

10.3390/pharmaceutics14102244

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

引用

页数：19

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