Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

被引：10
|
作者：
Rezaei, Zahra [1 ,2 ]
Yilmaz-Aykut, Dilara [1 ,3 ]
Tourk, Fatima Mumtaza [1 ,4 ]
Bassous, Nicole [1 ]
Barroso-Zuppa, Margot [1 ,5 ]
Shawl, Asif Iqbal [6 ]
Ashraf, Syed Salman [6 ,7 ,8 ,9 ]
Avci, Huseyin [10 ,11 ,12 ]
Hassan, Shabir [1 ,6 ,9 ]
机构：
[1] Harvard Med Sch, Div Engn Med, Brigham & Womens Hosp, Dept Med, Cambridge, MA 02139 USA
[2] Sharif Univ Technol, Chem Engn Dept, Azadi Ave, Tehran 1136511155, Iran
[3] Istanbul Univ Cerrahpasa, Fac Engn, Dept Chem Engn, TR-34320 Istanbul, Turkey
[4] Northeastern Univ, Dept Mech Engn, Boston, MA 02115 USA
[5] Tecnol Monterrey, Sch Med & Hlth Sci, Mexico City 14380, DF, Mexico
[6] Khalifa Univ, Coll Arts & Sci, Dept Biol, Main Campus,POB 127788, Abu Dhabi, U Arab Emirates
[7] Khalifa Univ, Ctr Biotechnol BTC, Main Campus,POB 127788, Abu Dhabi, U Arab Emirates
[8] Khalifa Univ, Ctr Catalysis & Separat CeCas, SAN Campus,POB 127788, Abu Dhabi, U Arab Emirates
[9] Khalifa Univ, Adv Mat Chem Ctr AMCC, SAN Campus,POB 127788, Abu Dhabi, U Arab Emirates
[10] Eskisehir Osmangazi Univ, Dept Met & Mat Engn, TR-26040 Eskisehir, Turkey
[11] Eskisehir Osmangazi Univ, Cellular Therapy & Stem Cell Res Ctr, TR-26040 Eskisehir, Turkey
[12] Eskisehir Osmangazi Univ, Translat Med Res & Clin Ctr, TR-26040 Eskisehir, Turkey
来源：
PHARMACEUTICS | 2022年 / 14卷 / 10期
关键词：
hydrogels; immune modulation; biomaterials; foreign body response; tissue engineering; REGULATORY T-CELLS; IMMUNE MODULATION; BIOMATERIALS; ANTIGEN; CANCER; ACID; IMMUNOTHERAPY; MACROPHAGES; PERFORMANCE; STRATEGIES;
D O I：
10.3390/pharmaceutics14102244
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.
引用
收藏
页数：19
相关论文
共 50 条
  • [1] Hydrogels and Their Applications in Targeted Drug Delivery
    Narayanaswamy, Radhika
    Torchilin, Vladimir P.
    MOLECULES, 2019, 24 (03):
  • [2] Drug delivery applications for superporous hydrogels
    Mastropietro, David J.
    Omidian, Hossein
    Park, Kinam
    EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (01) : 71 - 89
  • [3] Pectin Hydrogels as Structural Platform for Antibacterial Drug Delivery
    Saravanan, Tejas
    Pan, Jennifer M.
    Zingl, Franz G.
    Waldor, Matthew K.
    Zheng, Yifan
    Khalil, Hassan A.
    Mentzer, Steven J.
    POLYMERS, 2024, 16 (22)
  • [4] Environment sensitive hydrogels for drug delivery applications
    Qureshi, Dilshad
    Nayak, Suraj Kumar
    Maji, Samarendra
    Anis, Arfat
    Kim, Doman
    Pal, Kunal
    EUROPEAN POLYMER JOURNAL, 2019, 120
  • [5] Therapeutic applications of hydrogels in oral drug delivery
    Sharpe, Lindsey A.
    Daily, Adam M.
    Horava, Sarena D.
    Peppas, Nicholas A.
    EXPERT OPINION ON DRUG DELIVERY, 2014, 11 (06) : 901 - 915
  • [6] Hybrid Nanogels: Stealth and Biocompatible Structures for Drug Delivery Applications
    Eslami, Parisa
    Rossi, Filippo
    Fedeli, Stefano
    PHARMACEUTICS, 2019, 11 (02):
  • [7] Cation Exchange Hydrogels as Platform for Loading and Controlled Delivery of Drug
    Fundueanu, Gheorghe
    Constantin, Marieta
    Bucatariu, Sanda
    Mocanu, Georgeta
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2017, 17 (07) : 4643 - 4648
  • [8] Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases
    Liu, Lijia
    Wu, Dan
    Tu, Heng
    Cao, Mengjiao
    Li, Mengxin
    Peng, Li
    Yang, Jing
    GELS, 2023, 9 (02)
  • [9] Facile synthesis of biodegradable hydrogels for drug delivery applications
    Foster, Emily
    Morrell, Aidan
    Hao, Jing
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [10] An Extensive Review on Hydrogels in Pharmaceutical Drug Delivery Applications
    Rajaram, Subashini
    Dharmalingam, Senthil Rajan
    Natarajan, Vignesh
    Ravi, Kaveena
    Shanmugam, Nivetha
    Somasundaram, Subbhashini Maruthamuthu
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2022, 12 (02) : 108 - 112
12345