Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors

被引：19

作者：

Kao, Patrick Yu-Ping ^{[1
]}

Chan, Danny ^{[1
]}

Samartzis, Dino ^{[2
]}

Sham, Pak Chung ^{[3
]}

Song, You-Qiang ^{[1
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Biochem, Pokfulam, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Orthopaed & Traumatol, Div Spine Surg, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Queen Mary Hosp, Pokfulam, Hong Kong, Peoples R China

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2011年 / 42卷 / 04期

关键词：

Genetics; Lumbar disk degeneration; Association study; Twin studies; Familial aggregation;

D O I：

10.1016/j.ocl.2011.07.011

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years.

引用

页码：479 / +

页数：9

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