Direct Synthesis of Substituted Naphthalenes from 1,3-Dicarbonyl Compounds and 1,2-Bis(halomethyl)benzenes Including a Novel Rearrangement Aromatization of Benzo[c]oxepine

被引：29

作者：

Wang, Jun-gang ^{[1
]}

Wang, Meng ^{[1
]}

Xiang, Jia-chen ^{[1
]}

Zhu, Yan-ping ^{[1
]}

Xue, Wei-jian ^{[1
]}

Wu, An-xin ^{[1
]}

机构：

[1] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

基金：

中国国家自然科学基金;

关键词：

REGIOSELECTIVE SYNTHESIS; CARBENE COMPLEXES; CONCISE SYNTHESIS; RING-EXPANSION; ANNULATION; CYCLIZATION; EFFICIENT; ARYL; CONSTRUCTION; DERIVATIVES;

D O I：

10.1021/ol302950w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unexpected rearrangement aromatization of benzo[c]oxepine has been revealed to synthesize substituted naphthalenes. This observation was further exploited to develop an efficient approach for the construction of naphthalenes from simple and commercially available 1,3-dicarbonyl compounds and 1,2-bis(halomethyl)benzene compounds via a new domino reaction sequence.

引用

页码：6060 / 6063

页数：4

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