15N NMR of 1,4-dihydropyridine derivatives

被引：2

作者：

Goba, Inguna ^{[1
]}

Liepinsh, Edvards ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2013年 / 51卷 / 07期

关键词：

NMR; 15N NMR chemical shifts; 1HN NMR chemical shifts; 1J(15N-1H) coupling constants; substituent effect; solvent effect; quantum chemical calculations; 1; 4-DHP; SPIN COUPLING-CONSTANTS; CONFORMATIONAL-ANALYSIS; C-13; H-1; ANTAGONISTS; ASSIGNMENT; MECHANISM; N-15; BOND;

D O I：

10.1002/mrc.3959

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this article, we describe the characteristic 15N and 1HN NMR chemical shifts and 1J(15N-1H) coupling constants of various symmetrically and unsymmetrically substituted 1,4-dihydropyridine derivatives. The NMR chemical shifts and coupling constants are discussed in terms of their relationship to structural features such as character and position of the substituent in heterocycle, N-alkyl substitution, nitrogen lone pair delocalization within the conjugated system, and steric effects. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：391 / 396

页数：6

共 29 条

[21] Pihlaja K., 1994, Carbon-13 NMR chemical shifts in structural and stereochemical analysis
[22] INTERACTIONS BETWEEN NUCLEAR SPINS IN MOLECULES
RAMSEY, NF
PURCELL, EM
[J]. PHYSICAL REVIEW, 1952, 85 (01): : 143 - 144
[23] Electric field effects on one-bond indirect spin-spin coupling constants and possible Biomolecular perspectives
Sahakyan, Aleksandr B.
Shahkhatuni, Aleksan G.
Shahkhatuni, Astghik A.
Panosyan, Henry A.
[J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2008, 112 (16) : 3576 - 3586
[24] 1H and 13C spectral assignment of o-chloroformyl substituted 1,4-dihydropyridine derivatives
Suárez, M
Martín, N
Martínez, R
Verdecia, Y
Molero, D
Alba, L
Seoane, C
Ochoa, E
[J]. MAGNETIC RESONANCE IN CHEMISTRY, 2002, 40 (04) : 303 - 306
[25] Suárez M, 2011, J BRAZIL CHEM SOC, V22, P166, DOI 10.1590/S0103-50532011000100022
[26] The 1,4-Dihydropyridine Nucleus: A Pharmacophoric Template Part 1. Actions at Ion Channels
Triggle, David J.
[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (03) : 215 - 223
[27] Investigation of the NMR spin-spin coupling constants across the hydrogen bonds in ubiquitin: The nature of the hydrogen bond as reflected by the coupling mechanism
Tuttle, T
Kraka, E
Wu, AA
Cremer, D
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (16) : 5093 - 5107
[28] Vigante B. A., 1986, CHEM HETEROCYCL COMP, V22, P401, DOI 10.1007/BF00542779
[29] Dimethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Zhang, Zhenfeng
Xian, Dong
Wang, Jiange
Zhang, Guisheng
[J]. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2390 - +

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