Family-based association study in Tunisian familial psoriasis

被引:9
作者
Ammar, Myriam
Bouchlaka-Souissi, Chiraz
Zaraa, Ines
Helms, Cindy
Doss, Nejib
Bouazizi, Fatma
Dhaoui, Raouf
Ben Ossman, Amel
Ben Ammar-el Gaied, Amel
Mokni, Mourad
机构
[1] Fac Sci, Lab Genet Immunol & Human Pathol, Dept Biol, Tunis, Tunisia
[2] La Rabta Hosp, Dept Dermatol, Tunis, Tunisia
[3] Mil Hosp Tunis, Dept Dermatol, Tunis, Tunisia
[4] Washington Univ St Louis, Dept Human Genet, St Louis, MO USA
关键词
GENOME-WIDE SCAN; SUSCEPTIBILITY LOCUS; CANDIDATE; DISEASE; IDENTIFICATION; LINKAGE; GENES; POPULATIONS; RECEPTORS; SEARCH;
D O I
10.1111/j.1365-4632.2012.05523.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background The pathogenesis of all forms of psoriasis remains obscure. Segregation analysis and twin studies together with ethnic differences in disease frequency all point to an underlying genetic susceptibility to psoriasis, which is both complex and likely to reflect the action of a number of genes. Materials and methods In the present study, we performed a family-based association study, and a transmission dysequilibrium test using the PLINK program, in a set of seven Tunisian multiplex families using a panel of 96 single-nucleotide polymorphisms localized in several regions across the genome. Ninety-five of them were reported to be associated with psoriasis in different populations. Results Besides the confirmation of association between previous associated regions: 6p, 1p, 2p, 13q, 14q, and 20p, and cutaneous psoriasis, we identified a new association with the rs1249564 in the IL17RD gene. Conclusion Our results support the complex genetic basis of psoriasis.
引用
收藏
页码:1329 / 1334
页数:6
相关论文
共 26 条
[1]   THE PATHOPHYSIOLOGY OF PSORIASIS [J].
BARKER, JNWN .
LANCET, 1991, 338 (8761) :227-230
[2]   The genetics of psoriasis: a complex disorder of the skin and immune system [J].
Bhalerao, J ;
Bowcock, AM .
HUMAN MOLECULAR GENETICS, 1998, 7 (10) :1537-1545
[3]   The pathogenesis of psoriasis: Immunological facts and speculations [J].
Bos, JD ;
De Rie, MA .
IMMUNOLOGY TODAY, 1999, 20 (01) :40-46
[4]   A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].
Cargill, Michele ;
Schrodi, Steven J. ;
Chang, Monica ;
Garcia, Veronica E. ;
Brandon, Rhonda ;
Callis, Kristina P. ;
Matsunami, Nori ;
Ardlie, Kristin G. ;
Civello, Daniel ;
Catanese, Joseph J. ;
Leong, Diane U. ;
Panko, Jackie M. ;
McAllister, Linda B. ;
Hansen, Christopher B. ;
Papenfuss, Jason ;
Prescott, Stephen M. ;
White, Thomas J. ;
Leppert, Mark F. ;
Krueger, Gerald G. ;
Begovich, Ann B. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290
[5]   Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis [J].
de Cid, Rafael ;
Riveira-Munoz, Eva ;
Zeeuwen, Patrick L. J. M. ;
Robarge, Jason ;
Liao, Wilson ;
Dannhauser, Emma N. ;
Giardina, Emiliano ;
Stuart, Philip E. ;
Nair, Rajan ;
Helms, Cynthia ;
Escaramis, Georgia ;
Ballana, Ester ;
Martin-Ezquerra, Gemma ;
den Heijer, Martin ;
Kamsteeg, Marijke ;
Joosten, Irma ;
Eichler, Evan E. ;
Lazaro, Conxi ;
Pujol, Ramon M. ;
Armengol, Lluis ;
Abecasis, Goncalo ;
Elder, James T. ;
Novelli, Giuseppe ;
Armour, John A. L. ;
Kwok, Pui-Yan ;
Bowcock, Anne ;
Schalkwijk, Joost ;
Estivill, Xavier .
NATURE GENETICS, 2009, 41 (02) :211-215
[6]   Genetic Variations in Cytokines and Cytokine Receptors Associated with Psoriasis Found by Genome-Wide Association [J].
Duffin, Kristina Callis ;
Krueger, Gerald G. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (04) :827-833
[7]   IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease [J].
Einarsdottir, Elisabet ;
Koskinen, Lotta L. E. ;
Dukes, Emma ;
Kainu, Kati ;
Suomela, Sari ;
Lappalainen, Maarit ;
Ziberna, Fabiana ;
Korponay-Szabo, Ilma R. ;
Kurppa, Kalle ;
Kaukinen, Katri ;
Adany, Roza ;
Pocsai, Zsuzsa ;
Szeles, Gyorgy ;
Farkkila, Martti ;
Turunen, Ulla ;
Halme, Leena ;
Paavola-Sakki, Paulina ;
Not, Tarcisio ;
Vatta, Serena ;
Ventura, Alessandro ;
Lofberg, Robert ;
Torkvist, Leif ;
Bresso, Francesca ;
Halfvarson, Jonas ;
Maki, Markku ;
Kontula, Kimmo ;
Saarialho-Kere, Ulpu ;
Kere, Juha ;
D'Amato, Mauro ;
Saavalainen, Paivi .
BMC MEDICAL GENETICS, 2009, 10
[8]  
Ewens WJ, 2008, CURR PROT HUM GE JUL
[9]   Analysis of chromosome 5q31-32 and psoriasis:: Confirmation of a susceptibility locus but no association with SNPs within SLC22A4 and SLC22A5 [J].
Friberg, Camilla ;
Bjorck, Karin ;
Nilsson, Staffan ;
Inerot, Annica ;
Wahlstrom, Jan ;
Samuelsson, Lena .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (05) :998-1002
[10]   Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin [J].
Johansen, C. ;
Usher, P. A. ;
Kjellerup, R. B. ;
Lundsgaard, D. ;
Iversen, L. ;
Kragballe, K. .
BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (02) :319-324