Family-based association study in Tunisian familial psoriasis

被引：9

作者：

Ammar, Myriam

Bouchlaka-Souissi, Chiraz

Zaraa, Ines

Helms, Cindy

Doss, Nejib

Bouazizi, Fatma

Dhaoui, Raouf

Ben Ossman, Amel

Ben Ammar-el Gaied, Amel

Mokni, Mourad

机构：

[1] Fac Sci, Lab Genet Immunol & Human Pathol, Dept Biol, Tunis, Tunisia

[2] La Rabta Hosp, Dept Dermatol, Tunis, Tunisia

[3] Mil Hosp Tunis, Dept Dermatol, Tunis, Tunisia

[4] Washington Univ St Louis, Dept Human Genet, St Louis, MO USA

来源：

INTERNATIONAL JOURNAL OF DERMATOLOGY | 2012年 / 51卷 / 11期

关键词：

GENOME-WIDE SCAN; SUSCEPTIBILITY LOCUS; CANDIDATE; DISEASE; IDENTIFICATION; LINKAGE; GENES; POPULATIONS; RECEPTORS; SEARCH;

D O I：

10.1111/j.1365-4632.2012.05523.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background The pathogenesis of all forms of psoriasis remains obscure. Segregation analysis and twin studies together with ethnic differences in disease frequency all point to an underlying genetic susceptibility to psoriasis, which is both complex and likely to reflect the action of a number of genes. Materials and methods In the present study, we performed a family-based association study, and a transmission dysequilibrium test using the PLINK program, in a set of seven Tunisian multiplex families using a panel of 96 single-nucleotide polymorphisms localized in several regions across the genome. Ninety-five of them were reported to be associated with psoriasis in different populations. Results Besides the confirmation of association between previous associated regions: 6p, 1p, 2p, 13q, 14q, and 20p, and cutaneous psoriasis, we identified a new association with the rs1249564 in the IL17RD gene. Conclusion Our results support the complex genetic basis of psoriasis.

引用

页码：1329 / 1334

页数：6

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