Biomimetic growth of hydroxyapatite on phosphorylated electrospun cellulose nanofibers

被引：74

作者：

Li, Kaina ^{[1
]}

Wang, Jiangnan ^{[1
]}

Liu, Xinqing ^{[2
]}

Xiong, Xiaopeng ^{[3
]}

Liu, Haiqing ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Mat Sci & Engn, Key Lab Polymer Mat Fujian Prov, Fuzhou 350007, Fujian, Peoples R China

[2] Peoples Hosp Jiangxi Prov, Nanchang 330006, Peoples R China

[3] Xiamen Univ, Coll Mat, Dept Mat Sci & Engn, Xiamen 361005, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Electrospinning; Nanofiber; Hydroxyapatite; Cellulose biocomposite; BACTERIAL CELLULOSE; CALCIUM-PHOSPHATE; MINERALIZATION; NANOCOMPOSITE; SCAFFOLDS; MEMBRANES; FILMS;

D O I：

10.1016/j.carbpol.2012.07.033

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In biomimicking the formation of collagen fiber/hydroxyapatite (HAp) in natural bone, electrospun cellulose nanofiber(CelluNF)/HAp composites were synthesized in simulated body fluid (SBF). Their morphology and structure were characterized by SEM, TEM. XRD and XPS. CelluNFs showed low bioactivity in inducing the growth of HAp. In order to improve this ability. CelluNFs were slightly phosphorylated with a degree of substitution of phosphate group of 0.28. The modified CelluNFs were highly effective in guiding the HAp growth along the fibers. The HAp crystal size in the composites was ca. 24 nm, and the lattice spacing of (211) plane was 2.83 angstrom. It was found that the HAps in the composites were calcium deficient. The CelluNF/HAp composites are highly porous materials with micro-, meso-, and macro-pores. A mechanism for the HAp growth on CelluNFs was presented. Such CelluNF/HAp composites can be potentially useful in the field of bone tissue engineering. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1573 / 1581

页数：9

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