Math1:: An essential gene for the generation of inner ear hair cells

被引:872
作者
Bermingham, NA
Hassan, BA
Price, SD
Vollrath, MA
Ben-Arie, N
Eatock, RA
Bellen, HJ
Lysakowski, A
Zoghbi, HY [1 ]
机构
[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[4] Baylor Coll Med, Dev Biol Program, Houston, TX 77030 USA
[5] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
[6] Baylor Coll Med, Bobby R Alford Dept Otorhinolaryngol & Commun Sci, Houston, TX 77030 USA
[7] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA
关键词
D O I
10.1126/science.284.5421.1837
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.
引用
收藏
页码:1837 / 1841
页数:5
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