Hybrid Alginate-Based Cryogels for Life Science Applications

被引：16
作者：
Barros, Alexandre [1 ,2 ]
Quraishi, Sakeena [3 ]
Martins, Marta [1 ,2 ]
Gurikov, Pavel [3 ]
Subrahmanyam, Raman [3 ]
Smirnova, Irina [3 ]
Duarte, Ana Rita C. [1 ,2 ]
Reis, Rui L. [1 ,2 ]
机构：
[1] Univ Minho, Res Grp Biomat Biodegradables & Biomimet 3Bs, European Inst Excellence Tissue Engn & Regenerat, AvePk, P-4805017 Barco, Guimaraes, Portugal
[2] Univ Minho, ICVS PT Govt Associate Lab 3Bs, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal
[3] Hamburg Univ Technol, Inst Thermal Separat Proc, Eissendorfer Str 38, D-21073 Hamburg, Germany
来源：
CHEMIE INGENIEUR TECHNIK | 2016年 / 88卷 / 11期
关键词：
Alginate; Cryogel; Freeze-drying; CARBON-DIOXIDE; BIOMEDICAL APPLICATIONS; REGENERATIVE MEDICINE; HYDROGELS; FABRICATION; SCAFFOLDS; BEHAVIOR; BIOMATERIALS; DEGRADATION; AEROGELS;
D O I：
10.1002/cite.201600096
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) applications. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two-step process. Textural properties of the cryogels were analyzed by SEM and micro-computed tomography. The results indicated that rapid freezing retained sample shape and yielded macroporous materials. The mechanical properties of the cryogels were characterized in compression mode. Cytotoxicity studies indicated that the hybrid-alginate cryogels did not present cytotoxicity and have the potential to be used in TERM.
引用
收藏
页码：1770 / 1778
页数：9
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