An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head

被引：26

作者：

Liu, Baoyi ^{[1
,3
,4
,5
]}

Yang, Fan ^{[1
,2
]}

Wei, Xiaowei ^{[1
]}

Zhang, Xiuzhi ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Benjie ^{[1
]}

Liu, Ge ^{[1
]}

Xie, Hui ^{[1
]}

Yang, Jiahui ^{[1
]}

Wang, Wei ^{[1
]}

Qin, Kairong ^{[2
]}

Zhao, Dewei ^{[1
,2
]}

机构：

[1] Dalian Univ, Zhongshan Hosp, Dept Orthoped, 6 Jiefang St, Dalian, Liaoning, Peoples R China

[2] Dalian Univ Technol, Fac Elect Informat & Elect Engn, Dept Biomed Engn, Linggong Rd, Dalian, Peoples R China

[3] Dalian Univ, Zhongshan Hosp, Postdoctoral Workstn, 6 Jiefang St, Dalian, Liaoning, Peoples R China

[4] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China

[5] Jilin Univ, Inst Immunol, Changchun, Jilin, Peoples R China

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 99卷

基金：

中国国家自然科学基金;

关键词：

Osteonecrosis of femoral head; Bone marrow stromal stem cells; Bio-Gide collagen membrane; Porous tantalum; Full-thickness articular cartilage defect; REPAIR; COLLAPSE; DEFECTS; KNEE;

D O I：

10.1016/j.msec.2019.02.072

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.

引用

页码：1123 / 1132

页数：10

共 29 条

[1] TREATMENT OF DEEP CARTILAGE DEFECTS IN THE KNEE WITH AUTOLOGOUS CHONDROCYTE TRANSPLANTATION
BRITTBERG, M
LINDAHL, A
NILSSON, A
OHLSSON, C
ISAKSSON, O
PETERSON, L
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (14) : 889 - 895
[2] Vascularized Iliac Bone-Grafting for Osteonecrosis with Segmental Collapse of the Femoral Head
Chen, Chun-Chieh
Lin, Chun-Li
Chen, Wei-Chih
Shih, Hsin-Nung
Ueng, Steve W. N.
Lee, Mel S.
[J]. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2009, 91A (10) : 2390 - 2394
[3] Treatment of articular cartilage lesions of the knee
Falah, Mazen
Nierenberg, Gabreil
Soudry, Michael
Hayden, Morris
Volpin, Gershon
[J]. INTERNATIONAL ORTHOPAEDICS, 2010, 34 (05) : 621 - 630
[4] Fu WM, 2016, EUR REV MED PHARMACO, V20, P3490
[5] BIOCHEMICAL-STUDIES ON REPAIR CARTILAGE RESURFACING EXPERIMENTAL DEFECTS IN THE RABBIT KNEE
FURUKAWA, T
EYRE, DR
KOIDE, S
GLIMCHER, MJ
[J]. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1980, 62 (01) : 79 - 89
[6] Treating osteonecrosis with autologous bone marrow cells
Gangji, Valerie
Hauzeur, Jean-Philippe
[J]. SKELETAL RADIOLOGY, 2010, 39 (03) : 209 - 211
[7] Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair
Holland, T. A.
Bodde, E. W. H.
Cuijpers, V. M. J. I.
Baggett, L. S.
Tabata, Y.
Mikos, A. G.
Jansen, J. A.
[J]. OSTEOARTHRITIS AND CARTILAGE, 2007, 15 (02) : 187 - 197
[8] Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
Hunziker, EB
[J]. OSTEOARTHRITIS AND CARTILAGE, 2002, 10 (06) : 432 - 463
[9] Mid-term prognosis of non-traumatic osteonecrosis of the femoral head
Ito, H
Matsuno, T
Omizu, N
Aoki, Y
Minami, A
[J]. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2003, 85B (06): : 796 - 801
[10] Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, Jeffrey M.
Teol, Grace Sock Leng
[J]. CELL STEM CELL, 2009, 4 (03) : 206 - 216

← 1 2 3 →