Relation between left ventricular regional radial function and radial wall motion abnormalities using two-dimensional speckle tracking in children with idiopathic dilated cardiomyopathy

被引:44
作者
Friedberg, Mark Kevin [1 ]
Slorach, Cameron [1 ]
机构
[1] Hosp Sick Children, Labatt Family Heart Ctr, Div Paediat Cardiol, Toronto, ON M5G 1X8, Canada
关键词
D O I
10.1016/j.amjcard.2008.03.064
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Left ventricular (LV) regional radial function and its relation to radial wall motion abnormalities have not been investigated in children with idiopathic dilated cardiomyopathy (IDC). Radial strain was measured using 2-dimensional speckle tracking to evaluate regional radial function and wall motion in 6 LV segments in 24 children (0 to 18 years old) with IDC and 16 healthy controls. Patients and controls were similar in age. Patients with IDC had higher heart rates (97 +/- 28 vs 77 +/- 19, p <0.05) and decreased ejection fraction (34 +/- 12% vs 66 +/- 7%, p <0.0001) compared with controls. Radial strain in all segments was significantly lower in patients with IDC. In IDC, average radial strain correlated well with ejection fraction (r = 0.8, p <0.0001). The SD of time to peak radial strain among 6 LV segments was significantly higher in patients with IDC than in controls (56 38 vs 15 12 ms, p <0.0001). Segmental peak radial strain correlated closely to time to peak radial strain in controls (r = 0.98, p = 0.0008), but less in patients with IDC (r = 0.76, p = 0.07). In conclusion, LV regional radial function is impaired in pediatric IDC, in association with increased radial dyssynchrony, revealing a possible important mechanism for LV dysfunction in these children. (C) 2008 Elsevier Inc.
引用
收藏
页码:335 / 339
页数:5
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