Toll-Like Receptor Expression Pattern: Clinical Application

被引：3

作者：

Moossavi, Shirin ^{[5
]}

Rezaei, Nima ^{[1
,2
,3
,4
]}

机构：

[1] Childrens Med Ctr Hosp, Tehran 14194, Iran

[2] Univ Sheffield, Sch Med & Biomed Sci, Dept Infect & Immun, Sheffield, S Yorkshire, England

[3] Univ Tehran Med Sci, Sch Med, Dept Immunol, Mol Immunol Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, PediatricsCtr Excellence, Tehran, Iran

[5] Univ Tehran Med Sci, Digest Dis Res Ctr, Tehran, Iran

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2012年 / 32卷 / 06期

关键词：

Toll-like receptor; expression pattern; COLORECTAL-CANCER; MICROENVIRONMENT; TUMORS;

D O I：

10.1007/s10875-012-9719-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We read with interest the recent paper in the JoCI, entitled 'Study of the expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer' by Eir et al. TLR7 and 9 expression is altered in CRC vs. normal control; which is proposed to be correlated with adenomacarcinoma progression. The fact that other TLRs were not observed to be differentially expressed is in contrast with published reports; which could be explained by the limitations of the employed method and disregarding the spatiotemporal variation in TLR expression pattern.

引用

页码：1421 / 1422

页数：2

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