Immunohistochemical study of rat soleus muscle in various modes of denervation

被引：2

作者：

Islamov, RR ^{[1
]}

Guseva, DS ^{[1
]}

Chelyshev, YA ^{[1
]}

Valiullin, VV ^{[1
]}

机构：

[1] Kazan State Med Univ, Dept Histol, Kazan, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 04期

关键词：

denervation; slow muscle; myosins; immunohistochemistry;

D O I：

10.1023/A:1017985010156

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Immunohistochemical study with monoclonal antibodies against fast myosin heavy chains showed that excision of a fragment of sciatic nerve does not change, while compression of the nerve decreased the relative content of fast muscle fibers in rat soleus muscle. The content of fast fibers in the muscles of contralateral limbs decreased in both models of denervation. Hence, contralateral limbs cannot be used as the control in experiments with disturbed neurotrophic function. Possible mechanisms underlying changes in the immunohistochemical profiles of experimental and contralateral limbs are discussed.

引用

页码：403 / 406

页数：4

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