Noninvasive in vitro measurement of pig-blood D-glucose by using a microwave cavity sensor

被引：62

作者：

Kim, Seungwan ^{[1
,2
]}

Melikyan, Harutyun ^{[1
,2
]}

Kim, Jongchel ^{[1
,2
]}

Babajanyan, Arsen ^{[1
,2
]}

Lee, Jung-Ha ^{[2
,3
]}

Enkhtur, Lkhamsuren ^{[4
]}

Friedman, Barry ^{[5
]}

Lee, Kiejin ^{[1
,2
]}

机构：

[1] Sogang Univ, Dept Phys, Seoul 121742, South Korea

[2] Sogang Univ, Basic Sci Inst Cell Damage Control, Seoul 121742, South Korea

[3] Sogang Univ, Dept Life Sci, Seoul 121742, South Korea

[4] Natl Univ Mongolia, Dept Theoret & Expt Phys, Ulaanbaatar, Mongolia

[5] Sam Houston State Univ, Dept Phys, Huntsville, TX 77341 USA

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2012年 / 96卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Noninvasive; Real time monitoring; Pig blood; D-Glucose; Microwave cavity sensor; DIELECTRIC-PROPERTIES; CELL-MEMBRANE; TEMPERATURE; BIOSENSORS; INSULIN;

D O I：

10.1016/j.diabres.2012.01.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have developed an electromagnetic microwave cavity sensor based on the resonant frequency shift for real time measurement of the glycemia in pig blood. We could determine the concentration of D-glucose in pig blood in the range of 150-550 mg/dl at the resonance frequency near 4.75 GHz with a bandwidth of 300 MHz. The change in the D-glucose concentration in blood brings microwave reflection coefficient S-11 changes of about 6.26 dB and resonance frequency shifts of about 11.25 MHz due to the electromagnetic interaction between the cavity resonator and the blood filled plastic tube inserted into the cavity. This proposed system provides a unique approach for real time noninvasive and contactless glucose monitoring. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：379 / 384

页数：6

共 28 条

[1] Design of novel molecular wires for realizing long-distance electron transfer [J].

Albers, WM ;

Lekkala, JO ;

Jeuken, L ;

Canters, GW ;

Turner, APF .

BIOELECTROCHEMISTRY AND BIOENERGETICS, 1997, 42 (01) :25-33

[2]

AMATRUDA JM, 1979, J BIOL CHEM, V254, P2619

[3]

[Anonymous], DIAB ATL

[4] APPLICATION OF CHRONIC INTRAVASCULAR BLOOD-GLUCOSE SENSOR IN DOGS [J].

ARMOUR, JC ;

LUCISANO, JY ;

MCKEAN, BD ;

GOUGH, DA .

DIABETES, 1990, 39 (12) :1519-1526

[5]

CD Geddes, 2006, TOPICS FLUORESCENCE

[6] Monitoring glycemia in diabetes - Short-term assessment [J].

Goldstein, DE ;

Little, RR .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1997, 26 (03) :475-+

[7] Wideband ultralow reverberation antenna for biological sensing [J].

Hagness, SC ;

Taflove, A ;

Bridges, JE .

ELECTRONICS LETTERS, 1997, 33 (19) :1594-1595

[8] Adverse impact of temperature and humidity on blood glucose monitoring reliability: A pilot study [J].

Haller, Michael J. ;

Shuster, Jonathan J. ;

Schatz, Desmond ;

Melker, Richard J. .

DIABETES TECHNOLOGY & THERAPEUTICS, 2007, 9 (01) :1-9

[9] Dielectric spectroscopy study of specific glucose influence on human erythrocyte membranes [J].

Hayashi, Y ;

Livshits, L ;

Caduff, A ;

Feldman, Y .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (04) :369-374

[10] Temporal variation of dielectric properties of preserved blood [J].

Hayashi, Yoshihito ;

Oshige, Ikuya ;

Katsumoto, Yoichi ;

Omori, Shinji ;

Yasuda, Akio ;

Asami, Koji .

PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (01) :295-304

← 1 2 3 →