Estrogen-independent effects of ER-α36 in ER-negative breast cancer

被引：47
作者：
Zhang, Jing [2 ,3 ]
Li, Guangliang [2 ]
Li, Zhongqi [2 ]
Yu, Xiongfei [2 ]
Zheng, Yi [4 ]
Jin, Ketao [2 ]
Wang, Haohao [2 ]
Gong, Yun [3 ]
Sun, Xiaoping [5 ]
Teng, Xiaodong [6 ]
Cao, Jiang [1 ]
Teng, Lisong [2 ]
机构：
[1] Zhejiang Univ, Clin Res Ctr, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Surg Oncol, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[4] Zhejiang Univ, Dept Med Oncol, Affiliated Hosp 1, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
[5] Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Houston, TX 77030 USA
[6] Zhejiang Univ, Dept Pathol, Affiliated Hosp 1, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
STEROIDS | 2012年 / 77卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Estrogen receptor-alpha 36; Breast cancer; Paclitaxel; Metastasis; RECEPTOR-ALPHA; ADJUVANT CHEMOTHERAPY; VARIANT; EXPRESSION; PACLITAXEL; INHIBITION; RESISTANCE; APOPTOSIS; PROTEIN; KINASE;
D O I：
10.1016/j.steroids.2012.02.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Estrogen receptor-alpha 36 (ER-alpha 36) is a variant of ER-alpha that has been found to be expressed in conventional ER (ER-alpha 66)-negative breast cancer cell lines and human breast cancer samples. In this study, we found that, using immunohistochemical study. ER-alpha 36 expression was significantly higher in ER-negative tumors than in ER-positive tumors although the expression was not associated with other clinicopathological characteristics. We then constructed an ER-alpha 36-specific microRNA hairpin vector and established stable ER-alpha 36 knockdown cells, and found that the knockdown cells were more sensitive to paclitaxel; the c-Jun N-terminal kinase pathway appeared to be involved in the mechanism. Downregulation of ER-alpha 36 also resulted in decreased migration and invasion. These changes were estrogen independent. Our findings indicated that target ER-alpha 36 may be a strategy for treating ER-negative breast cancers. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：666 / 673
页数：8
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