Pulsed Dendritic Cells for the Therapy of Experimental Glioma

被引：3

作者：

Chekhonin, I. V. ^{[1
]}

Gurina, O. I. ^{[1
]}

Cherepanov, S. A. ^{[2
]}

Abakumov, M. A. ^{[2
]}

Ionova, K. P. ^{[1
]}

Zhigarev, D. K. ^{[1
]}

Makarov, A. V. ^{[1
]}

Chekhonin, V. P. ^{[1
,2
]}

机构：

[1] Minist Hlth Russian Federat, VP Serbsky Fed Med Res Ctr Psychiat & Narcol, Moscow, Russia

[2] NI Pirogov Russian Natl Res Med Univ, Med Biol Fac, Dept Med Nanobiotechnol, Minist Hlth Russian Federat, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 06期

关键词：

dendritic cells; glioma; neurospecific proteins; angiogenesis; periglioma zone; MONOCLONAL-ANTIBODIES; C6; GLIOMA;

D O I：

10.1007/s10517-016-3512-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.

引用

页码：792 / 796

页数：5

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