The influence of G-quadruplex structure on DNA-based asymmetric catalysis using the G-quadruplex-bound cationic porphyrin TMPyP4•Cu

被引：57

作者：

Wilking, Michael ^{[1
]}

Hennecke, Ulrich ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 40期

关键词：

TELOMERIC G-QUADRUPLEX; HYDRATION;

D O I：

10.1039/c3ob41366g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The DNA G-quadruplex-binding porphyrin TMPyP4 center dot Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3'-face.

引用

页码：6940 / 6945

页数：6

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