Proteolysis dysfunction in the process of aging and age-related diseases

被引：33

作者：

Frankowska, Natalia ^{[1
]}

Lisowska, Katarzyna ^{[1
]}

Witkowski, Jacek M. ^{[1
]}

机构：

[1] Med Univ Gdansk, Fac Med, Dept Physiopathol, Gdansk, Poland

来源：

FRONTIERS IN AGING | 2022年 / 3卷

关键词：

aging; proteostasis; chaperones; ubiquitin-proteasome system; autophagy; lysosome; proteases; T-CELLS; PROTEASOME STRUCTURE; CALPAIN INHIBITION; SIGNALING PATHWAYS; 20S PROTEASOME; AUTOPHAGY; CHAPERONE; EXPRESSION; CASPASES; DEGRADATION;

D O I：

10.3389/fragi.2022.927630

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In this review, we discuss in detail the most relevant proteolytic systems that together with chaperones contribute to creating the proteostasis network that is kept in dynamic balance to maintain overall functionality of cellular proteomes. Data accumulated over decades demonstrate that the effectiveness of elements of the proteostasis network declines with age. In this scenario, failure to degrade misfolded or faulty proteins increases the risk of protein aggregation, chronic inflammation, and the development of age-related diseases. This is especially important in the context of aging-related modification of functions of the immune system.

引用

页数：16

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