Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer

被引：16
作者：
Bayani, Jane [2 ]
Paliouras, Miltiadis [1 ,3 ]
Planque, Chris [1 ,3 ]
Shan, Shannon J. C. [4 ]
Graham, Cassandra [2 ]
Squire, Jeremy A. [5 ]
Diamandis, Eleftherios P. [1 ,3 ]
机构：
[1] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5T 3L9, Canada
[2] Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Dept Appl Mol Oncol, Toronto, ON M5G 2M9, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada
[4] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA
[5] Queens Univ, Richardson Lab, Dept Pathol & Mol Med, Kingston, ON K7L 3N6, Canada
来源：
MOLECULAR ONCOLOGY | 2008年 / 2卷 / 03期
关键词：
Ovarian cancer; Human kallikreins; Chromosomal rearrangements;
D O I：
10.1016/j.molonc.2008.07.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tissue kallikrein (KLK) genes are a new source for biomarkers in ovarian cancer. However, there has been no systematic analysis of copy number and structural rearrangements related to their protein expression. Chromosomal rearrangements and copy number changes of the KLK region were studied by FISH with protein levels measured by ELISA. Ovarian cancer and cell lines revealed the KLK region was subject to copy number imbalances or involved in unbalanced translocations and were associated with increased protein expression of KLKs 5, 6, 7, 8, 9, 10 and 11. in this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers. (C) 2008 Federation of European Biochemical Societies Published by Elsevier B.V. All rights reserved
引用
收藏
页码：250 / 260
页数：11
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